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Title: | A Change in the Epidemiology of Infections Due to Extended-Spectrum b-Lactamase–Producing Organisms |
Authors: | Rodriguez-Baño, Jesus Paterson, David L. |
metadata.dc.contributor.authoraffiliation: | [Rodriguez-Baño,J] Sección de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Seville, Spain. [Paterson ,DL]Division of Infectious Diseases, University of Pittsburgh Medical |
Keywords: | epidemiology;beta-lactamase;epidemiologia;beta-lactamases |
metadata.dc.subject.mesh: | Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Bacteremia Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross Infection Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Enterobacteriaceae Infections Medical Subject Headings::Anatomy::Fluids and Secretions::Feces Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Amidohydrolases::beta-Lactamases |
Issue Date: | 1-Apr-2006 |
Publisher: | University of Chicago Press |
Citation: | Rodriguez-Baño J, Paterson DL. A Change in the Epidemiology of Infections Due to Extended-Spectrum b-Lactamase–Producing Organisms. Clin Infect Dis. (2006) 42 (7): 935-937 |
Abstract: | Extended-spectrum β-lactamases (ESBLs) form a heterogeneous group that share the property of hydrolytic activity against the oxyimino-β-lactams while remaining susceptible to inhibition by β-lactamase inhibitors, such as clavulanic acid. From a clinical point of view, they are important because they confer resistance to penicillins, aztreonam, and cephalosporins, and ESBL-producing organisms are typically also resistant to aminoglycosides, trimethoprim-sulfamethoxazole, and quinolones [1]. Until recently, the main problem posed by ESBLs was related to nosocomial outbreaks caused by ESBL-producing Klebsiella species. These outbreaks are usually clonal, the strains are mainly spread through cross-transmission, and the risk factors are similar to those found for other multidrug-resistant nosocomial pathogens [2]. In Europe and the United States, most ESBL-producing Klebsiella isolates harbored enzymes belonging to the TEM and SHV families [3]. Detection of colonized patients by performing surveillance cultures within affected units, isolation precautions for colonized patients, and restriction of oxyimino-β-lactam use are frequently useful for the control of these outbreaks [1]. There is no evidence that hospital-acquired ESBL-producing klebsiellae are decreasing in importance—in fact, data from the Centers for Disease Control and Prevention show that 20.6% of Klebsiella pneumoniae isolates from United States intensive care units in 2003 were probable producers of ESBL [4]. This represented a 47% increase, compared with the preceding 5 years. However, during the last few years, an impressive increase in the number of ESBL-producing Escherichia coli (and, less frequently, other Enterobacteriaceae) is being described in several parts of the world [5–8]. This emergent phenomenon shows some differences from the problem posed by Klebsiella species; many of these ESBL-producing E. coli are isolated … |
URI: | http://hdl.handle.net/10668/403 |
metadata.dc.relation.publisherversion: | http://cid.oxfordjournals.org/content/42/7/935.full |
metadata.dc.identifier.doi: | 10.1086/500945 |
ISSN: | 1058-4838 |
Appears in Collections: | 01- Artículos - Hospital Virgen Macarena |
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RodriguezBano_AChangeof.pdf | Editorial | 53,92 kB | Adobe PDF | View/Open |
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