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Title: The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer
Authors: Palma, Pablo
Conde-Muíño, Raquel
Rodríguez-Fernández, Antonio
Segura-Jiménez, Inmaculada
Sánchez-Sánchez, Rocío
Martín-Cano, Javier
Gómez-Río, Manuel
Ferrón, José A
Llamas-Elvira, José M
metadata.dc.contributor.authoraffiliation: [Palma,P; Conde-Muíño,R; Segura-Jiménez,I; Martín-Cano,J; Ferrón,JA] Division of Colon &Rectal Surgery - Department of Surgery, HUVN Granada, Spain. [Rodríguez-Fernández,A; Sánchez-Sánchez,R; Gómez-Río,M; Llamas-Elvira, JM] Department of Nuclear Medicine, HUVN Granada, Spain
Keywords: Adulto;Anciano;Anciano de 80 o más Años;Carcinoma;Quimioterapia;Terapia Combinada;Femenino;Fluorodesoxiglucosa F18;Humanos;Masculino;Mediana Edad;Tomografía de Emisión de Positrones;Valor Predictivo de las Pruebas;Pronóstico;Neoplasias del Recto;Sensibilidad y Especificidad
metadata.dc.subject.mesh: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged::Aged, 80 and over
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Chemotherapy, Adjuvant
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Combined Modality Therapy
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Deoxy Sugars::Deoxyglucose::Fluorodeoxyglucose F18
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Tomography, Emission-Computed::Positron-Emission Tomography
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Sensitivity and Specificity::Predictive Value of Tests
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Rectal Neoplasms
Medical Subject Headings::Check Tags::Female
Issue Date: 15-Dec-2010
Publisher: BioMed Central
Citation: Palma P, Conde-Muíño R, Rodríguez-Fernández A, Segura-Jiménez I, Sánchez-Sánchez R, Martín-Cano J, et al. The value of metabolic imaging to predict tumour response after chemoradiation in locally advanced rectal cancer. Radiat Oncol. 2010 Dec 15;5:119
Abstract: Background: We aim to investigate the possibility of using 18F-positron emission tomography/computer tomography (PET-CT) to predict the histopathologic response in locally advanced rectal cancer (LARC) treated with preoperative chemoradiation (CRT). Methods: The study included 50 patients with LARC treated with preoperative CRT. All patients were evaluated by PET-CT before and after CRT, and results were compared to histopathologic response quantified by tumour regression grade (patients with TRG 1-2 being defined as responders and patients with grade 3-5 as non-responders). Furthermore, the predictive value of metabolic imaging for pathologic complete response (ypCR) was investigated. Results: Responders and non-responders showed statistically significant differences according to Mandard's criteria for maximum standardized uptake value (SUVmax) before and after CRT with a specificity of 76,6% and a positive predictive value of 66,7%. Furthermore, SUVmax values after CRT were able to differentiate patients with ypCR with a sensitivity of 63% and a specificity of 74,4% (positive predictive value 41,2% and negative predictive value 87,9%); This rather low sensitivity and specificity determined that PET-CT was only able to distinguish 7 cases of ypCR from a total of 11 patients. Conclusions: We conclude that 18-F PET-CT performed five to seven weeks after the end of CRT can visualise functional tumour response in LARC. In contrast, metabolic imaging with 18-F PET-CT is not able to predict patients with ypCR accurately
Description: Preliminary data of this work were presented by RCM and awarded at the 2009 Annual Meeting of the Spanish Society of Coloproctology (AECP) held in Barcelona.
metadata.dc.identifier.doi: 10.1186/1748-717X-5-119
ISSN: 1748-717X (Online)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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