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Título : A specific protein-enriched enteral formula decreases cortisolemia and improves plasma albumin and amino acid concentrations in elderly patients
Autor : Olza, Josune
Mesa, María D
Poyatos, Rafael M
Aguilera, Concepción M
Moreno-Torres, Rosario
Pérez, Milagros
Pérez de la Cruz, Antonio
Gil, Angel
Filiación: [Olza,J;Mesa,MD;Aguilera,CM;Gil,A] Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Biomedical Research Center, University of Granada, Granada, Spain. [Poyatos,M] Clinical Analysis Service, University Hospital Virgen de las Nieves, Granada, Spain. [Moreno-Torres,R;Pérez de la Cruz,A] Clinical Nutrition and Dietetic Unit, University Hospital Virgen de las Nieves, Granada, Spain. [Pérez,M] Department of I+D Vegenat S.A, Pueblonuevo del Guadiana, Badajoz, Spain
Palabras clave : Anciano;Nutrición Enteral;Aminoácidos, Péptidos y Proteínas;Sarcopenia;Alimentos Fortificados
MeSH: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Nutritional Support::Enteral Nutrition
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Neuromuscular Manifestations::Muscular Atrophy::Sarcopenia
Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Foods, Specialized::Food, Fortified
Fecha de publicación : 13-jul-2010
Editorial : BioMed Central
Abstract: Background: Old age is associated with an involuntary and progressive but physiological loss of muscle mass. The aim of this study was to evaluate the effects of exclusive consumption for 6 months of a protein-enriched enteral diet with a relatively high content of branched-chain amino acids on albuminemia, cortisolemia, plasma aminoacids, insulin resistance, and inflammation biomarkers in elderly patients. Methods: Thirty-two patients from the Clinical Nutrition Outpatient Unit at our hospital exclusively consumed a protein-enriched enteral diet for 6 months. Data were collected at baseline and at 3 and 6 months on anthropometric and biochemical parameters and on plasma concentrations of amino acids, cortisol,adrenocorticotropic hormone, urea, creatinine, insulin resistance, and inflammation biomarkers. Results: The percentage of patients with albumin concentration below normal cut-off values decreased from 18% to 0% by the end of the study. At 6 months, concentrations of total plasma (p = 0.008) and essential amino acids(p = 0.011), especially branched-chain amino acids (p = 0.031), were higher versus baseline values, whereas 3-methylhistidine (p = 0.001), cortisol (p = 0.001) and adrenocorticotropic hormone (p = 0.004) levels were lower. Conclusions: Regular intake of specific protein-enriched enteral formula increases plasma essential amino acids, especially branched-chain amino acids, and decreases cortisol and 3-methylhistidine, while plasma urea and creatinine remain unchanged.
URI: http://hdl.handle.net/10668/415
Versión del editor : http://www.nutritionandmetabolism.com/content/7/1/58
DOI: 10.1186/1743-7075-7-58
ISSN : 1743-7075 (Online)
Aparece en las colecciones: 01- Artículos - Hospital Virgen de las Nieves

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