Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/4403
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dc.contributor.authorTrillo-Contreras, José Luis-
dc.contributor.authorToledo-Aral, Juan José-
dc.contributor.authorVilladiego, Javier-
dc.contributor.authorEchevarría, Miriam-
dc.date.accessioned2022-11-25T08:33:50Z-
dc.date.available2022-11-25T08:33:50Z-
dc.date.issued2021-09-09-
dc.identifier.citationTrillo-Contreras JL, Toledo-Aral JJ, Villadiego J, Echevarría M. Aquaporin-4 Mediates Permanent Brain Alterations in a Mouse Model of Hypoxia-Aged Hydrocephalus. Int J Mol Sci. 2021 Sep 9;22(18):9745es_ES
dc.identifier.issn1422-0067 (Online)es_ES
dc.identifier.otherPMC8471142es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4403-
dc.description.abstractAquaporin-4 (AQP4) is the principal water channel in the brain being expressed in astrocytes and ependymal cells. AQP4 plays an important role in cerebrospinal fluid (CSF) homeostasis, and alterations in its expression have been associated with hydrocephalus. AQP4 contributes to the development of hydrocephalus by hypoxia in aged mice, reproducing such principal characteristics of the disease. Here, we explore whether these alterations associated with the hydrocephalic state are permanent or can be reverted by reexposure to normoxia. Alterations such as ventriculomegaly, elevated intracranial pressure, and cognitive deficits were reversed, whereas deficits in CSF outflow and ventricular distensibility were not recovered, remaining impaired even one month after reestablishment of normoxia. Interestingly, in AQP4-/- mice, the impairment in CSF drainage and ventricular distensibility was completely reverted by re-normoxia, indicating that AQP4 has a structural role in the chronification of those alterations. Finally, we show that aged mice subjected to two hypoxic episodes experience permanent ventriculomegaly. These data reveal that repetitive hypoxic events in aged cerebral tissue promote the permanent alterations involved in hydrocephalic pathophysiology, which are dependent on AQP4 expression.es_ES
dc.description.sponsorshipThis study was supported by grants FIS: PI16/00493 and PI19/01096 from the Spanish Ministry of Economy and Competitiveness, co-financed by the Carlos III Health Institute (ISCIII) and European Regional Development Fund (FEDER).es_ES
dc.format.extent13 p.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.relation.ispartofInternational Journal of Molecular Scienceses_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAQP4es_ES
dc.subjectAstrocyteses_ES
dc.subjectHypoxiaes_ES
dc.subjectHydrocephaluses_ES
dc.subjectCerebrospinal fluides_ES
dc.subjectCerebral ventricleses_ES
dc.subjectHomeostasises_ES
dc.subjectDrainagees_ES
dc.subjectAcuaporina 4es_ES
dc.subjectAstrocitoses_ES
dc.subjectHipoxiaes_ES
dc.subjectHidrocefaliaes_ES
dc.subjectLíquido cefalorraquídeoes_ES
dc.subjectVentrículos cerebraleses_ES
dc.subjectDrenajees_ES
dc.subject.meshMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Age Factorses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Porins::Aquaporins::Aquaporin 4es_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacologicales_ES
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::Braines_ES
dc.subject.meshMedical Subject Headings::Diseases::Animal Diseases::Disease Models, Animales_ES
dc.subject.meshMedical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Hydrocephaluses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Histocytochemistry::Immunohistochemistryes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaginges_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Micees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotypees_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibilityes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Neuroglia::Astrocyteses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasises_ES
dc.subject.meshMedical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Intracranial Hypertensiones_ES
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognitiones_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drainagees_ES
dc.titleAquaporin-4 Mediates Permanent Brain Alterations in a Mouse Model of Hypoxia-Aged Hydrocephaluses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.versionYeses_ES
dc.identifier.pmid34575909es_ES
dc.rights.accessRightsAcceso abiertoes_ES
dc.identifier.doi10.3390/ijms22189745es_ES
dc.type.versioninfo:eu-repo/semantics/publishedes_ES
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/18/9745/htmes_ES
dc.contributor.authoraffiliation[Trillo-Contreras,JL; Toledo-Aral,JJ; Villadiego,J; Echevarría,M] Institute of Biomedicine of Seville-IBiS, University Hospital Virgen del Rocío, CSIC, University of Seville, Seville, Spain. [Trillo-Contreras,JL; Toledo-Aral,JJ; Villadiego,J; Echevarría,M] Department of Medical Physiology and Biophysics, University of Seville, Seville, Spain. [Toledo-Aral,JJ; Villadiego,J] Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spaines_ES
dc.type.subtypeArtículo originales_ES
Appears in Collections:01- Artículos - Hospital Virgen del Rocío
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla

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