Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/470
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGonzalez-Calvin, Jorge L-
dc.contributor.authorMundi, Jose L-
dc.contributor.authorCasado-Caballero, Francisco J-
dc.contributor.authorAbadia, Ana C-
dc.contributor.authorMartin-Ibanez, Jose J-
dc.date.accessioned2012-09-12T10:36:05Z-
dc.date.available2012-09-12T10:36:05Z-
dc.date.issued2009-12-
dc.identifier.citationGonzález-Calvin JL, Mundi JL, Casado-Caballero FJ, Abadia AC, Martin-Ibañez JJ. Bone mineral density and serum levels of soluble tumor necrosis factors, estradiol, and osteoprotegerin in postmenopausal women with cirrhosis after viral hepatitis. J Clin Endocrinol Metab. 2009 Dec;94(12):4844-50es
dc.identifier.issn0021-972X (Print)-
dc.identifier.issn1945-7197 (Online)-
dc.identifier.urihttp://hdl.handle.net/10668/470-
dc.description.abstractCONTEXT: Cirrhosis after viral hepatitis has been identified as a risk factor for osteoporosis in men. However, in postmenopausal women, most studies have evaluated the effect of primary biliary cirrhosis, but little is known about the effect of viral cirrhosis on bone mass [bone mineral density (BMD)] and bone metabolism. OBJECTIVE: Our objective was to assess the effect of viral cirrhosis on BMD and bone metabolism in postmenopausal women. DESIGN: We conducted a cross-sectional descriptive study. SETTING AND PATIENTS: We studied 84 postmenopausal female outpatients with viral cirrhosis and 96 healthy postmenopausal women from the general community. BMD was measured by dual-energy x-ray absorptiometry at lumbar spine (LS) and femoral neck (FN). RESULTS: The percentage with osteoporosis did not significantly differ between patients (LS, 43.1%; FN, 32.2%) and controls (LS, 41.2%; FN, 29.4%), and there was no difference in BMD (z-score) between groups. Serum concentrations of soluble TNF receptors, estradiol, and osteoprotegerin (OPG) were significantly higher in patients vs. controls (P < 0.001, P < 0.05, and P < 0.05, respectively). No significant difference was observed in urinary deoxypyridinoline. Serum OPG levels were positively correlated with soluble TNF receptors (r = 0.35; P < 0.02) and deoxypyridinoline (r = 0.37; P < 0.05). CONCLUSIONS: This study shows that bone mass and bone resorption rates do not differ between postmenopausal women with viral cirrhosis and healthy postmenopausal controls and suggests that viral cirrhosis does not appear to increase the risk of osteoporosis in these women. High serum estradiol and OPG concentrations may contribute to preventing the bone loss associated with viral cirrhosis in postmenopausal women.es
dc.description.sponsorshipThis work was supported by a grant from Consejería de Salud, Junta de Andalucía (PI-0134/2007).es
dc.language.isoenes
dc.publisherEndocrine Societyes
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismes
dc.subjectAbsorciometría de Fotónes
dc.subjectAminoácidoses
dc.subjectDensidad Óseaes
dc.subjectHuesoses
dc.subjectEstudios Transversaleses
dc.subjectEstradioles
dc.subjectHepatitis Viral Humanaes
dc.subjectCirrosis Hepáticaes
dc.subjectMediana Edades
dc.subjectOsteoprotegerinaes
dc.subjectPosmenopausiaes
dc.subjectReceptor Activator of Nuclear Factor-kappa Bes
dc.subjectReceptores del Factor de Necrosis Tumorales
dc.subjectFactores de Riesgoes
dc.subjectFactores de Necrosis Tumorales
dc.subjectAnciano de 80 o más Añoses
dc.subjectAncianoes
dc.subjectFemeninaes
dc.subjectHumanoses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Radiography::Absorptiometry, Photones
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acidses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Densityes
dc.subject.meshMedical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Boneses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studieses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormone Antagonists::Estrogen Receptor Modulators::Estrogen Antagonists::Estradiol Antagonistses
dc.subject.meshMedical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Humanes
dc.subject.meshMedical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Cirrhosises
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Tumor Necrosis Factor::Tumor Necrosis Factor Decoy Receptors::Osteoprotegerines
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Climacteric::Menopause::Postmenopausees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Tumor Necrosis Factor::Receptor Activator of Nuclear Factor-kappa Bes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Tumor Necrosis Factores
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factorses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factorses
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Agedes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged::Aged, 80 and overes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.titleBone Mineral Density and Serum Levels of Soluble Tumor Necrosis Factors, Estradiol, and Osteoprotegerin in Postmenopausal Women with Cirrhosis after Viral Hepatitises
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid19897681-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1210/jc.2009-0835-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://jcem.endojournals.org/content/94/12/4844.longes
dc.contributor.authoraffiliation[González-Calvin, JL; Mundi, JL; Casado-Caballero, FC; Martin-Ibañez, JL] Department of Gastroenterology, University Hospital San Cecilio. [Abadia, A ] Department of Biochemistry and Molecular Biology III and Immunology (A.C.A.), University of Granada, 18001 Granada Spaines
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital San Cecilio

Files in This Item:
File Description SizeFormat 
GonzalezBone2009.pdfArticulo publicado126,36 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons