Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/475
Title: Acquisition and cross-transmission of Staphylococcus aureus in European intensive care units
Authors: Bloemendaal, AL
Fluit, AC
Jansen, WM
Vriens, MR
Ferry, T
Argaud, L
Amorim, JM
Resende, AC
Pascual, A
López-Cerero, L
Stefani, S
Castiglione, G
Evangelopoulou, P
Tsiplakou, S
Rinkes, IH
Verhoef, J
metadata.dc.contributor.authoraffiliation: [Bloemendaal,AL;Fluit,AC;Jansen,WM;Verhoef,J] Department of Medical Microbiology University Medical Center Utrecht, Utrecht, the Netherlands. [Bloemendaal,AL;Vriens,MR;Rinkes,IH] Department of Surgery University Medical Center Utrecht, Utrecht, the Netherlands. [Ferry,T] Université Lyon, Centre National de Référence des Staphylocoques, Faculté Laennec. [Argaud,A;Resende,AC] Service de Réanimation Médicale Pôle d’Activité d’Urgences et de Réanimation Médicales Groupement Hospitalier Edouard Herriot Hospices Civils de Lyon,Lyon, France. [Amorim,JM] Department of Microbiology, Hospital Geral de Santo Antonio, Porto, Portugal. [Pascual,A;López-Cerero,L] Department of Microbiology, Hospital Virgen Macarena, Seville, Spain. [Stefani,S] Department of Microbiology Vittorio Emanuele Hospital, Catania, Italy.[Castiglione,G]Intensive Care Unit Ward, Vittorio Emanuele Hospital, Catania, Italy.[Evangelopoulou,P]Athens University School of Nursing, Intensive Care Unit,Athens, Greece.[Tsiplakou,S] Microbiology and Immunology Department, KAT Hospital, Athens, Greece.
Keywords: Cross-transmission;Staphylococcus aureus;Intensive care units;Transmisión cruzada;Estafilococi aureo;Unidades de cuidados intensivos
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross Infection
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Drug Resistance, Microbial::Drug Resistance, Bacterial::Drug Resistance, Multiple, Bacterial
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Molecular Biology::Molecular Epidemiology
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Public Health Practice::Communicable Disease Control::Handwashing
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Personnel::Infection Control Practitioners
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins::Methicillin
Medical Subject Headings::Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Staphylococcaceae::Staphylococcus::Staphylococcus aureus::Methicillin-Resistant Staphylococcus aureus
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Tests
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Staphylococcal Infections
Medical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Gram-Positive Cocci::Staphylococcaceae::Staphylococcus::Staphylococcus aureus
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
Issue Date: Feb-2009
Publisher: University of Chicago Press
Citation: Bloemendaal AL, Fluit AC, Jansen WM, Vriens MR, Ferry T, Argaud L, et al.Acquisition and cross-transmission of Staphylococcus aureus in European intensive care units. Infect Control Hosp Epidemiol. 2009 Feb;30(2):117-24.
Abstract: Objective. To study the acquisition and cross-transmission of Staphylococcus aureus in different intensive care units (ICUs). Methods. We performed a multicenter cohort study. Six ICUs in 6 countries participated. During a 3-month period at each ICU, all patients had nasal and perineal swab specimens obtained at ICU admission and during their stay. All S. aureus isolates that were collected were genotyped by spa typing and multilocus variable-number tandem-repeat analysis typing for cross-transmission analysis. A total of 629 patients were admitted to ICUs, and 224 of these patients were found to be colonized with S. aureus at least once during ICU stay (22% were found to be colonized with methicillin-resistant S. aureus [MRSA]). A total of 316 patients who had test results negative for S. aureus at ICU admission and had at least 1 follow-up swab sample obtained for culture were eligible for acquisition analysis. Results. A total of 45 patients acquired S. aureus during ICU stay (31 acquired methicillin-susceptible S. aureus [MSSA], and 14 acquired MRSA). Several factors that were believed to affect the rate of acquisition of S. aureus were analyzed in univariate and multivariate analyses, including the amount of hand disinfectant used, colonization pressure, number of beds per nurse, antibiotic use, length of stay, and ICU setting (private room versus open ICU treatment). Greater colonization pressure and a greater number of beds per nurse correlated with a higher rate of acquisition for both MSSA and MRSA. The type of ICU setting was related to MRSA acquisition only, and the amount of hand disinfectant used was related to MSSA acquisition only. In 18 (40%) of the cases of S. aureus acquisition, cross-transmission from another patient was possible. Conclusions. Colonization pressure, the number of beds per nurse, and the treatment of all patients in private rooms correlated with the number of S. aureus acquisitions on an ICU. The amount of hand disinfectant used was correlated with the number of cases of MSSA acquisition but not with the number of cases of MRSA acquisition. The number of cases of patient-to-patient cross-transmission was comparable for MSSA and MRSA.
URI: http://hdl.handle.net/10668/475
metadata.dc.relation.publisherversion: http://www.jstor.org/stable/10.1086/593126
metadata.dc.identifier.doi: 10.1086/593126
ISSN: 0899-823X (Print)
1559-6834 (Online)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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