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Title: Quantitative electroencephalography reveals different physiological profiles between benign and remitting-relapsing multiple sclerosis patients
Authors: Vazquez-Marrufo, Manuel
Gonzalez-Rosa, Javier J
Vaquero, Encarnacion
Duque, Pablo
Borges, Monica
Gomez, Carlos
Izquierdo, Guillermo
metadata.dc.contributor.authoraffiliation: [Vazquez-Marrufo,M; Gonzalez-Rosa,JJ; Vaquero,E; Gomez,C] Laboratory of Psychophysiology, Department of Experimental Psychology, University of Seville, Seville, Spain. [Vazquez-Marrufo,M; Gonzalez-Rosa,JJ; Duque,P; Borges,M; Izquierdo,G] Multiple Sclerosis Unit, Virgen Macarena Hospital, Seville, Spain
Keywords: benign multiple sclerosis;electroencephalography;relapsing-remitting multiple sclerosis;;eslerosis múltiple benigna;electroencelografía;recaída-remisión de esclerosis múltiple
metadata.dc.subject.mesh: Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Electrodiagnosis::Electroencephalography
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Nervous System Diseases::Demyelinating Diseases::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic Progressive
Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Relapsing-Remitting
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Psychomotor Performance
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Reaction Time
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Issue Date: 24-Nov-2008
Publisher: BioMed Central
Citation: Vazquez-Marrufo M, Gonzalez-Rosa JJ, Vaquero E, Duque P, Borges M, Gomez C, et al. Quantitative electroencephalography reveals different physiological profiles between benign and remitting-relapsing multiple sclerosis patients. BMC Neurol; 8:44
Abstract: BACKGROUND A possible method of finding physiological markers of multiple sclerosis (MS) is the application of EEG quantification (QEEG) of brain activity when the subject is stressed by the demands of a cognitive task. In particular, modulations of the spectral content that take place in the EEG of patients with multiple sclerosis remitting-relapsing (RRMS) and benign multiple sclerosis (BMS) during a visuo-spatial task need to be observed. METHODS The sample consisted of 19 patients with RRMS, 10 with BMS, and 21 control subjects. All patients were free of medication and had not relapsed within the last month. The power spectral density (PSD) of different EEG bands was calculated by Fast-Fourier-Transformation (FFT), those analysed being delta, theta, alpha, beta and gamma. Z-transformation was performed to observe individual profiles in each experimental group for spectral modulations. Lastly, correlation analyses was performed between QEEG values and other variables from participants in the study (age, EDSS, years of evolution and cognitive performance). RESULTS Nearly half (42%) the RRMS patients showed a statistically significant increase of two or more standard deviations (SD) compared to the control mean value for the beta-2 and gamma bands (F = 2.074, p = 0.004). These alterations were localized to the anterior regions of the right hemisphere, and bilaterally to the posterior areas of the scalp. None of the BMS patients or control subjects had values outside the range of +/- 2 SD. There were no significant correlations between these values and the other variables analysed (age, EDSS, years of evolution or behavioural performance). CONCLUSION During the attentional processing, changes in the high EEG spectrum (beta-2 and gamma) in MS patients exhibit physiological alterations that are not normally detected by spontaneous EEG analysis. The different spectral pattern between pathological and controls groups could represent specific changes for the RRMS patients, indicative of compensatory mechanisms or cortical excitatory states representative of some phases during the RRMS course that are not present in the BMS group.
Description: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1186/1471-2377-8-44
ISSN: 1471-2377 (Online)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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