Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/491
Título : High Prevalence of Systemic Autoimmune Diseases in Patients with Meniere's Disease
Autor : Gazquez, Irene
Soto-Varela, Andres
Aran, Ismael
Santos, Sofia
Batuecas, Angel
Trinidad, Gabriel
Perez-Garrigues, Herminio
Gonzalez-Oller, Carlos
Acosta, Lourdes
Lopez-Escamez, Jose A
Filiación: [Gazquez,I; Lopez-Escamez,JA] Genyo, Centro de Genómica e Investigación Oncológica, Pfizer/Universidad de Granada/Junta de Andalucia, Granada, Spain. [Soto-Varela,A; Santos,S] Division Otoneurology, Department of Otorhinolaryngology, Complejo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela, Spain. [Aran,I] Department of Otolaryngology, Complejo Hospitalariode Pontevedra, Pontevedra, Spain. [Batuecas,A] Department Otolaryngology, Hospital Universitario Salamanca, Salamanca, Spain. [Trinidad,G] Department Otolaryngology, Hospital Universitario de Badajoz, Badajoz, Spain. [Perez-Garrigues,H] Division Otoneurology, Department of Otorhinolaryngology, Hospital La Fe, Valencia, Spain. [Gonzalez-Oller,C; Acosta,L] Otology & Neurotology Group, CTS495, Department of Biotechnology, Hospital de Poniente, El Ejido, Almeria, Spain. [Lopez-Escamez JA] Otology & Neurotology Group, CTS495, Department of Otolaryngology, Hospital de Poniente, El Ejido, Almeria, Spain.
Palabras clave : Interferon-gamma
Tumor Necrosis Factor-alpha
Enfermedad de Meniere
Enfermedades Autoinmunes
Pérdida Auditiva Sensorineural
Vértigo
Prevalencia
MeSH: Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Hearing Loss::Hearing Loss, Sensorineural
Medical Subject Headings::Information Science::Information Science::Data Collection::Vital Statistics::Morbidity::Prevalence
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Causality::Risk Factors
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Interferons::Interferon-gamma
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Models, Statistical::Linear Models
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Labyrinth Diseases::Vestibular Diseases::Vertigo
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Diseases::Nervous System Diseases::Neurologic Manifestations::Vertigo
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Labyrinth Diseases::Endolymphatic Hydrops::Meniere Disease
Fecha de publicación : 28-Oct-2011
Editorial : Public Library of Science (PLoS)
Cita Bibliográfica: Gazquez I, Soto-Varela A, Aran I, Santos S, Batuecas A, Trinidad G, et al. High prevalence of systemic autoimmune diseases in patients with Menière's disease. PLoS ONE; 6(10):e26759
Abstract: BACKGROUND. Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes of vertigo associated with hearing loss and tinnitus. However, the prevalence of autoimmune diseases (AD) in patients with MD has not been studied in individuals with uni or bilateral sensorineural hearing loss (SNHL). METHODS AND FINDINGS. We estimated the prevalence of AD in 690 outpatients with MD with uni or bilateral SNHL from otoneurology clinics at six tertiary referral hospitals by using clinica criteria and an immune panel (lymphocyte populations, antinuclear antibodies, C3, C4 and proinflammatory cytokines TNFα, INFγ). The observed prevalence of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) was higher than expected for the general population (1.39 for RA, 0.87 for SLE and 0.70 for AS, respectively). Systemic AD were more frequently observed in patients with MD and diagnostic criteria for migraine than cases with MD and tension-type headache (p = 0.007). There were clinical differences between patients with uni or bilateral SNHL, but no differences were found in the immune profile. Multiple linear regression showed that changes in lymphocytes subpopulations were associated with hearing loss and persistence of vertigo, suggesting a role for the immune response in MD. CONCLUSIONS. Despite some limitations, MD displays an elevated prevalence of systemic AD such as RA, SLE and AS. This finding, which suggests an autoimmune background in a subset of patients with MD, has important implications for the treatment of MD.
URI: http://hdl.handle.net/10668/491
Versión del editor : http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0026759
DOI: 10.1371/journal.pone.0026759
ISSN : 1932-6203
Appears in Collections:01- Artículos - GENYO. Centro Pfizer-Andalucía de Genómica e Investigación Oncológica
01- Artículos - APES Hospital de Poniente

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