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Title: Total antioxidant capacity of plasma in asymptomatic carrier state of Neisseria meningitidis
Authors: Uberos, J
Molina-Carballo, A
Galdo-Muñoz, G
Muñoz-Hoyos, A
metadata.dc.contributor.authoraffiliation: [Uberos,J; Molina-Carballo,A; Galdo-Muñoz,G; Muñoz-Hoyos, A] Departamento de Pediatría, Hospital Clínico San Cecilio, Granada, Spain
Keywords: Portador Sano;Antioxidantes;Preescolar;Niño;Humanos;Infantil;Recién nacido;Infecciones Meningocócicas;Nasofaringe
metadata.dc.subject.mesh: Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Carrier State
Medical Subject Headings::Named Groups::Persons::Age Groups::Child
Medical Subject Headings::Named Groups::Persons::Age Groups::Child::Child, Preschool
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Named Groups::Persons::Age Groups::Infant
Medical Subject Headings::Named Groups::Persons::Age Groups::Infant::Infant, Newborn
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Neisseriaceae Infections::Meningococcal Infections
Medical Subject Headings::Anatomy::Respiratory System::Pharynx::Nasopharynx
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants
Issue Date: Jul-2007
Publisher: Cambridge University Press
Citation: Uberos J, Molina-Carballo A, Galdo-Muñoz G, Muñoz-Hoyos A. Total antioxidant capacity of plasma in asymptomatic carrier state of Neisseria meningitidis. Epidemiol. Infect.. 2007 Jul; 135(5):857-60
Abstract: Reduction of the antioxidant capacity of plasma has been linked with the impairment of an effective immune response and so we hypothesized that the carriage rate of Neisseria meningitidis in asymptomatic subjects might correlate with the levels of antioxidants in plasma. To this end we took pharyngeal swabs from 339 children in Marquesado Basic Health Zone, Granada, Spain and in addition determined the total antioxidant capacity (TAC) in plasma samples from these subjects. The overall prevalence of N. meningitidis carriage was 5.9% (mean age 7.1 years) with rates of 10.3% in children aged 3 < or =years, 3.9% between 4 and 7 years and 2.4% in older subjects. Plasma TAC for the < or =3-year-olds was 0.13 for carriers and 1.10 for non-carrier controls (P=0.04), 0.13 for carriers aged 4-7 years (controls 0.63) and 0.28 for carriers aged >7 years (controls 0.52). We analysed the association between TAC in plasma (<0.37 - 2 S.D.) and the carrier state of N. meningitidis. In the carrier state, the odds ratio for this association (TAC in plasma <0.25) was 8.44 (95% CI 1.5-48.9). These findings may suggest a reduced immune response in the host favourable to nasopharyngeal persistence of meningococci.
Description: Journal Article;
metadata.dc.identifier.doi: 10.1017/S0950268806007539
ISSN: 0950-2688 (Print)
1469-4409 (Online)
Appears in Collections:01- Artículos - Hospital San Cecilio

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