Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/574
Title: Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus
Authors: Sánchez, Elena
Sabio, José M
Callejas, José L
Ramón, Enrique de
Garcia-Portales, Rosa
García-Hernández, Francisco J
Jiménez-Alonso, Juan
González-Escribano, Ma Francisca
Martín, Javier
Koeleman, Bobby P
metadata.dc.contributor.authoraffiliation: [Sánchez,E; Martín,J] Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain. [Sabio,JM; Jiménez-Alonso,J] Servicio de Medicina Interna, Hospital Virgen de las Nieves, Granada, Spain. [Callejas,JL] Servicio de Medicina Interna, Hospital Clínico San Cecilio, Granada, Spain. [Ramón,E de] Servicio de Medicina Interna, Hospital Carlos-Haya, Málaga, Spain. [Garcia-Portales,R] Servicio de Reumatología, Hospital Virgen de la Victoria, Málaga, Spain. [García-Hernández,FJ] Servicio de Medicina Interna, Hospital Virgen del Rocio, Sevilla, Spain. [ González-Escribano,MF] Servicio de Inmunología, Hospital Virgen del Rocío, Sevilla, Spain. [Koeleman,BP] Department of Biomedical Genetics, Utrecht University Medical Centre, Utrecht, The Netherlands.
Keywords: Adulto;Quimiocina CCL2;Quimiocina CCL5;Quimiocinas;Femenino;Predisposición Genética a la Enfermedad;Genotipo;Humanos;Inflamación;Interleucina-1;Interleucina-8;Interleucinas;Lupus Eritematoso Sistémico;Masculino;Polimorfismo de Nucleótido Simple
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Chemokines::Chemokines, CC::Chemokine CCL20
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Chemokines::Chemokines, CC::Chemokine CCL5
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Chemokines
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-1
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Chemokines::Chemokines, CXC::Interleukin-8
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Lupus Erythematosus, Systemic
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins
Issue Date: 23-May-2006
Publisher: BioMed Central
Citation: Sánchez E, Sabio JM, Callejas JL, Ramón E de, Garcia-Portales E, García-Hernández FJ et al. Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus. BMC Med Genet. 2006 May 23;7:48.
Abstract: BACKGROUND. Several lines of evidence suggest that chemokines and cytokines play an important role in the inflammatory development and progression of systemic lupus erythematosus. The aim of this study was to evaluate the relevance of functional genetic variations of RANTES, IL-8, IL-1alpha, and MCP-1 for systemic lupus erythematosus. METHODS. The study was conducted on 500 SLE patients and 481 ethnically matched healthy controls. Genotyping of polymorphisms in the RANTES, IL-8, IL-1alpha, and MCP-1 genes were performed using a real-time polymerase chain reaction (PCR) system with pre-developed TaqMan allelic discrimination assay. RESULTS. No significant differences between SLE patients and healthy controls were observed when comparing genotype, allele or haplotype frequencies of the RANTES, IL-8, IL-1alpha, and MCP-1 polymorphisms. In addition, no evidence for association with clinical sub-features of SLE was found. CONCLUSION. These results suggest that the tested functional variation of RANTES, IL-8, IL-1alpha, and MCP-1 genes do not confer a relevant role in the susceptibility or severity of SLE in the Spanish population.
Description: Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/574
metadata.dc.relation.publisherversion: http://www.biomedcentral.com/1471-2350/7/48
metadata.dc.identifier.doi: 10.1186/1471-2350-7-48
ISSN: 1471-2350 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital San Cecilio
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - Hospital Virgen de las Nieves
01- Artículos - Hospital Virgen del Rocío

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