Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/575
Title: Residential Exposure to Outdoor Air Pollution during Pregnancy and Anthropometric Measures at Birth in a Multicenter Cohort in Spain
Authors: Estarlich, Marisa
Ballester, Ferran
Aguilera, Inmaculada
Fernández-Somoano, Ana
Lertxundi, Aitana
Llop, Sabrina
Freire, Carmen
Tardón, Adonina
Basterrechea, Mikel
Sunyer, Jordi
Iñiguez, Carmen
metadata.dc.contributor.authoraffiliation: [Estarlich,M;Ballester,F;Aguilera,I; Fernandez-Somoano,A; Lertxundi,A; Llop,S; Freire,C; Tardon,A; Basterrechea,M; Sunyer,J; Iniguez,C] Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain. [Estarlich,M;Ballester,F; Llop,S; Iniguez,C] Center for Public Health Research (CSISP), Valencia, Spain. [Estarlich,M; Ballester,F; Iniguez,C] University of Valencia, Valencia, Spain. [Aguilera,I; Sunyer,J] Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. [Aguilera,I; Sunyer,J] Hospital del Mar Research Institute (IMIM), Barcelona, Spain. [Fernandez-Somoano,A; Tardon,A] Department of Preventive Medicine, University of Oviedo, Asturias, Spain. [Lertxundi,A; Basterrechea,M] Public Health Division of Gipuzkoa, Basque Government, Gipuzkoa, Spain. [Lertxundi,A] Department of Preventive Medicine and Public Health, (EHU-UPV), University of the Basque Country, Gipuzkoa, Spain. [Freire,C] Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, Granada, Spain. [Sunyer, J] Pompeu Fabra University, Barcelona, Spain
Keywords: Emisiones de Vehículos;Dióxido de Nitrógeno;Benceno;Contaminantes del Aire;Adulto;Peso al Nacer;Tamaño Corporal;Estudios de Cohortes;Monitoreo del Ambiente;Femenina;Humanos;Recién Nacido;Recién Nacido Pequeño para la Edad Gestacional;Exposición por Inhalación;Exposición Materna;Embarazo;Estudios Prospectivos;Questionnaires;Distribución Espacial de la Población;España;Adulto Joven;Air Pollution;Anthropometry;Benzene;Birth;Birth weight;Nitrogen dioxide;Pregnancy
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Air Pollutants
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Environmental Monitoring
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Named Groups::Persons::Age Groups::Infant::Infant, Newborn
Medical Subject Headings::Named Groups::Persons::Age Groups::Infant::Infant, Newborn::Infant, Low Birth Weight::Infant, Small for Gestational Age
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Inhalation Exposure
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure
Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Nitrogen Compounds::Nitrogen Oxides
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Questionnaires
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Residence Characteristics
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Chemicals and Drugs::Complex Mixtures::Vehicle Emissions
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young Adult
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Issue Date: Sep-2011
Publisher: National Institute of Environmental Health Sciences (NIEHS)
Citation: Estarlich M, Ballester F, Aguilera I, Fernández-Somoano A, Lertxundi A, Llop S, et al. Residential exposure to outdoor air pollution during pregnancy and anthropometric measures at birth in a multicenter cohort in Spain. Environ. Health Perspect.. 2011 Sep; 119(9):1333-8
Abstract: BACKGROUND. A growing body of research suggests that prenatal exposure to air pollution may be harmful to fetal development. We assessed the association between exposure to air pollution during pregnancy and anthropometric measures at birth in four areas within the Spanish Children's Health and Environment (INMA) mother and child cohort study. METHODS. Exposure to ambient nitrogen dioxide (NO2) and benzene was estimated for the residence of each woman (n = 2,337) for each trimester and for the entire pregnancy. Outcomes included birth weight, length, and head circumference. The association between residential outdoor air pollution exposure and birth outcomes was assessed with linear regression models controlled for potential confounders. We also performed sensitivity analyses for the subset of women who spent more time at home during pregnancy. Finally, we performed a combined analysis with meta-analysis techniques. RESULTS. In the combined analysis, an increase of 10 µg/m3 in NO2 exposure during pregnancy was associated with a decrease in birth length of -0.9 mm [95% confidence interval (CI), -1.8 to -0.1 mm]. For the subset of women who spent ≥ 15 hr/day at home, the association was stronger (-0.16 mm; 95% CI, -0.27 to -0.04). For this same subset of women, a reduction of 22 g in birth weight was associated with each 10-µg/m3 increase in NO2 exposure in the second trimester (95% CI, -45.3 to 1.9). We observed no significant relationship between benzene levels and birth outcomes. CONCLUSIONS. NO2 exposure was associated with reductions in both length and weight at birth. This association was clearer for the subset of women who spent more time at home.
Description: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't. Reproduced with permission from Environmental Health Perspectives
URI: http://hdl.handle.net/10668/575
metadata.dc.relation.publisherversion: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230392/?report=abstract
metadata.dc.identifier.doi: 10.1289/ehp.1002918
ISSN: 1552-9924 (Online)
0091-6765 (Print)
Appears in Collections:01- Artículos - Hospital San Cecilio

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