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Title: 8-weeks training program attenuates mitochondrial oxidative stress in the liver of emotionally stressed rats
Authors: Rosety-Rodriguez, M
Ordonez, F J
Rosety, I
Frias, L
Rosety, M A
Rosety, J M
Rosety, M
metadata.dc.contributor.authoraffiliation: [Rosety-Rodriguez, M] Medicine Department, Sport Medicine School, University of Cadiz, Spain. [Ordonez, FJ; Rosety M] Human Anatomy and Embryology Department, Sport Medicine School, University of Cadiz, Spain. [Rosety, I; Frías, L] School of Veterinary, University of Cordoba, Spain. [Rosety, MA] School of Sport Sciences, University of Wales, United Kingdom. [Rosety, JM] University Hospital Puerta del Mar, Andalusian Health Service, Cadiz, Spain.
Keywords: Exercise;Mitochondria;Oxidative Stress;Emotional stress;Ejercicio;Mitocondrias;Estrés oxidativo;Estrés emocional;Conducta animal;Hígado;Condicionamiento físico animal;Ratas;Ratas Wistar;Oxigeno
metadata.dc.subject.mesh: Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavior, Animal
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism::Oxidation-Reduction
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Stress, Physiological::Oxidative Stress
Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Gases::Oxygen
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Physical Conditioning, Animal
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar
Medical Subject Headings::Disciplines and Occupations::Human Activities::Leisure Activities::Recreation::Sports::Running
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Stress, Psychological
Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time Factors
Medical Subject Headings::Organisms::Eukaryota::Animals
Issue Date: Nov-2006
Publisher: Universidad de Murcia
Citation: Rosety-Rodriguez M, Ordonez FJ, Rosety I, Frias L, Rosety MA, Rosety JM, et al. 8-weeks training program attenuates mitochondrial oxidative stress in the liver of emotionally stressed rats. Histol. Histopathol.. 2006 Nov; 21(11):1167-70
Abstract: In recent years it has been shown that emotional stress induced by immobilization may change the balance between pro-oxidant and antioxidant factors inducing oxidative damage. On the other hand, contradictory views exist concerning the role of physical activity on redox metabolism. Consequently, the present work was designed to assess the influence of an 8-week moderate swimming training program in emotionally stressed rats. Sixty 1-month-old male albino Wistar rats weighing 125-135 g were used in this experimental study. They were divided into three groups, as Control (lot A; n=20), Stressed (lot B; n=20) and Stressed & Exercised (lot C; n=20). Rats were stressed by placing the animals in a 25 x 7 cm plastic bottle 1 h/day, 5 days a week for 8 weeks. Protein carbonyl content values in liver homogenates were significantly increased in stressed animals (0.58+/-0.02 vs 0.86+/-0.03; p=0.018) which clearly indicated that emotional stress was associated with oxidative stress. Ultrastructural alterations, predominantly mitochondrial swelling and the decrease of cristae number observed by electron microscopy represented direct evidence of membrane injury. The most striking feature of our study was that we also found differences between stressed rats and stressed rats that performed our 8 week training program. Consequently our results highlight the potential benefit of a moderate training program to reduce oxidative damage induced by emotional stress since it attenuated protein oxidation and mitochondrial alterations.
Description: Journal Article;
ISSN: 1699-5848 (Online)
0213-3911 (Print)
Appears in Collections:01- Artículos - Hospital Puerta del Mar

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