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Title: Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects.
Authors: Marco, Eva M
García-Gutiérrez, María S
Bermúdez-Silva, Francisco-Javier
Moreira, Fabricio A
Guimarães, Francisco
Manzanares, Jorge
Viveros, María-Paz
metadata.dc.contributor.authoraffiliation: [Marco,EM; Viveros,MP]Departamento de Fisiología (Fisiología AnimalII),Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Madrid, Spain. Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain. [García-Gutiérrez, MS; Manzanares, J] Instituto de Neurosciencias de Alicante, Universidad Miguel Hernández - CSIC, San Juan de Alicante, Spain. [Bermúdez-Silva, FJ]Laboratorio de Medicina Regenerativa, Hospital Carlos Haya de Málaga, Fundacion IMABIS, Malaga, Spain. Neurocentre Magendie, INSERM, Université bordeaux 2, Bordeaux, France. [Moreira, FA]Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. [Guimarães, F]Department of Pharmacology, School of Medicine of Riveirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Keywords: Cannabinoid Receptor;emotion;receptores de cannabinoides;emoción;cannabidiol;cognition;emotion;anxiety;depression;schizophrenia;eating disorders
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Cannabinoids::Cannabidiol
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Eating Disorders
Issue Date: 5-Oct-2011
Publisher: Frontiers Research Foundation
Viviana Trezza, Roma tre University, Italy
Citation: Marco EM, García-Gutiérrez MS, Bermúdez-Silva FJ, Moreira FA, Guimarães F, Manzanares J, et al. Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects. Front Behav Neurosci. 2011; 5:63
Abstract: Public concern on mental health has noticeably increased given the high prevalence of neuropsychiatric disorders. Cognition and emotionality are the most affected functions in neuropsychiatric disorders, i.e., anxiety disorders, depression, and schizophrenia. In this review, most relevant literature on the role of the endocannabinoid (eCB) system in neuropsychiatric disorders will be presented. Evidence from clinical and animal studies is provided for the participation of CB1 and CB2 receptors (CB1R and CB2R) in the above mentioned neuropsychiatric disorders. CBRs are crucial in some of the emotional and cognitive impairments reported, although more research is required to understand the specific role of the eCB system in neuropsychiatric disorders. Cannabidiol (CBD), the main non-psychotropic component of the Cannabis sativa plant, has shown therapeutic potential in several neuropsychiatric disorders. Although further studies are needed, recent studies indicate that CBD therapeutic effects may partially depend on facilitation of eCB-mediated neurotransmission. Last but not least, this review includes recent findings on the role of the eCB system in eating disorders. A deregulation of the eCB system has been proposed to be in the bases of several neuropsychiatric disorders, including eating disorders. Cannabis consumption has been related to the appearance of psychotic symptoms and schizophrenia. In contrast, the pharmacological manipulation of this eCB system has been proposed as a potential strategy for the treatment of anxiety disorders, depression, and anorexia nervosa. In conclusion, the eCB system plays a critical role in psychiatry; however, detrimental consequences of manipulating this endogenous system cannot be underestimated over the potential and promising perspectives of its therapeutic manipulation.
Description: Journal Article;
metadata.dc.identifier.doi: 10.3389/fnbeh.2011.00063
ISSN: 1662-5153 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga

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