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Title: Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance
Authors: Tinahones Madueño, Francisco José
Cardona Díaz, Fernando
Rojo-Martínez, Gemma
Almaraz, María de la Cruz
Cardona, Isabel
Vázquez-Mellado, J
Garrido-Sánchez, Lourdes
Collantes, E
Soriguer Escofet, Federico
metadata.dc.contributor.authoraffiliation: [Tinahones Madueño,FJ; Cardona Díaz,F] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Rojo-Martínez,G; Cardona,I; Garrido-Sánchez,L] Fundación IMABIS (Instituto Mediterráneo para el Avance de la Biotecnología y la Investigación Sanitaria), Málaga, Spain. [Almaraz,MC; Soriguer Escofet,F] Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Vázquez-Mellado,J] Hospital General Ciudad de México, México. [Collantes,E] Servicio de Reumatología, Hospital Universitario Reina Sofía de Córdoba, Spain
Keywords: OGTT;Glucemia;Colesterol;HDL-Colesterol;Prueba de Tolerancia a la Glucosa;Insulina;Resistencia a la Insulina;Estrés Oxidativo;Análisis de Regresión;Triglicéridos;Ácido úrico;Uric acid;Insulin resistance;OGTT;Triacylglycerol
metadata.dc.subject.mesh: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose::Blood Glucose
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Cholestanes::Cholestenes::Cholesterol
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, HDL::Cholesterol, HDL
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Clinical Chemistry Tests::Blood Chemical Analysis::Glucose Tolerance Test
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pancreatic Hormones::Insulins
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis
Medical Subject Headings::Chemicals and Drugs::Lipids::Glycerides::Triglycerides
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Alkaloids::Xanthines::Uric Acid
Medical Subject Headings::Named Groups::Persons::Age Groups::Adolescent
Issue Date: Jan-2008
Publisher: Cambridge University Press
Citation: Tinahones Madueño FJ, Cardona Díaz F, Rojo-Martínez G, Almaraz MC, Cardona I, Vázquez-Mellado J, et al. Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance. Br. J. Nutr.. 2008; 99(1):44-8
Abstract: Hyperuricaemia is one of the components of metabolic syndrome. Both oxidative stress and hyperinsulinism are important variables in the genesis of this syndrome and have a close association with uric acid (UA). We evaluated the effect of an oral glucose challenge on UA concentrations. The study included 656 persons aged 18 to 65 years. Glycaemia, insulin, UA and plasma proteins were measured at baseline and 120 min after an oral glucose tolerance test (OGTT). The baseline sample also included measurements of total cholesterol, triacylglycerol (TAG) and HDL-cholesterol. Insulin resistance was calculated with the homeostasis model assessment. UA levels were significantly lower after the OGTT (281.93 (sd 92.19) v. 267.48 (sd 90.40) micromol/l; P < 0.0001). Subjects with a drop in UA concentrations >40.86 micromol/l (>75th percentile) had higher plasma TAG levels (P = 0.0001), baseline insulin (P = 0.02) and greater insulin resistance (P = 0.034). Women with a difference in plasma concentrations of UA above the 75th percentile had higher baseline insulin levels (P = 0.019), concentration of plasma TAG (P = 0.0001) and a greater insulin resistance index (P = 0.029), whereas the only significant difference in men was the level of TAG. Multiple regression analysis showed that the basal TAG levels, insulin at 120 min, glycaemia at 120 min and waist:hip ratio significantly predicted the variance in the UA difference (r2 0.077). Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels.
Description: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1017/S0007114507787470
ISSN: 1475-2662 (Online)
0007-1145 (Print)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Reina Sofía
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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