Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/632
Título : CD209 in inflammatory bowel disease: a case-control study in the Spanish population
Autor : Núñez, Concepción
Oliver, Javier
Mendoza, Juan L
Gómez-García, María
Taxonera, Carlos
Gómez, Luis M
López-Nevot, Miguel A
G de laConcha, Emilio
Urcelay, Elena
Martínez, Alfonso
Martín, Javier
Filiación: [Núñez,C; G de la Concha,E; Urcelay,E; Martínez,A] Servicio de Inmunología Clínica, Hospital Clínico San Carlos, Madrid, Spain.[Oliver,J; Gómez,LM; Martín,J] Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain.[Mendoza,JL; Taxonera,C] Unidad de Enfermedad Inflamatoria Intestinal, Hospital Clínico San Carlos, Madrid, Spain. [Gómez-García,M] Unidad de Enfermedad Inflamatoria Intestinal, Hospital Virgen de las Nieves, Granada, Spain. [López-Nevot,MA] Servicio de Inmunología, Hospital Virgen de las Nieves, Granada, Spain.
Palabras clave : Adulto
Estudios de Casos y Controles
Moléculas de Adhesión Celular
Distribución de Chi-Cuadrado
Colitis Ulcerosa
Enfermedad de Crohn
Femenino
Frecuencia de los Genes
Marcadores Genéticos
Predisposición Genética a la Enfermedad
Genotipo
Antígenos HLA-DR
Humanos
Lectinas Tipo C
Masculino
Mediana Edad
Polimorfismo de Nucleótido Simple
Receptores de Superficie Celular
España
MeSH: Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Cell Adhesion Molecules
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Statistical Distributions::Chi-Square Distribution
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn Disease
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Gene Frequency
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Genetic Markers
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Lectins::Lectins, C-Type
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Fecha de publicación : 10-Dec-2007
Editorial : BioMed Central
Cita Bibliográfica: Núñez C, Oliver J, Mendoza JL, Gómez-García M, Taxonera C, Gómez LM et al. CD209 in inflammatory bowel disease: a case-control study in the Spanish population. BMC Med Genet. 2007 Dec 10;8:75.
Abstract: BACKGROUND The etiology of Ulcerative Colitis (UC) and Crohn's Disease (CD), considered together as Inflammatory Bowel Diseases (IBD), involves environmental and genetic factors. Although some genes are already known, the genetics underlying these diseases is complex and new candidates are continuously emerging. The CD209 gene is located in a region linked previously to IBD and a CD209 functional polymorphism (rs4804803) has been associated to other inflammatory conditions. Our aim was to study the potential involvement of this CD209 variant in IBD susceptibility. METHODS We performed a case-control study with 515 CD patients, 497 UC patients and 731 healthy controls, all of them white Spaniards. Samples were typed for the CD209 single nucleotide polymorphism (SNP) rs4804803 by TaqMan technology. Frequency comparisons were performed using chi2 tests. RESULTS No association between CD209 and UC or CD was observed initially. However, stratification of UC patients by HLA-DR3 status, a strong protective allele, showed that carriage of the CD209_G allele could increase susceptibility in the subgroup of HLA-DR3-positive individuals (p = 0.03 OR = 1.77 95% CI 1.04-3.02, vs. controls). CONCLUSION A functional variant in the CD209 gene, rs4804803, does not seem to be influencing Crohn's disease susceptibility. However, it could be involved in the etiology or pathology of Ulcerative Colitis in HLA-DR3-positive individuals but further studies are necessary.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/632
Versión del editor : http://www.biomedcentral.com/1471-2350/8/75
DOI: 10.1186/1471-2350-8-75
ISSN : 1471-2350 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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