Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/634
Título : Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor.
Autor : Balsa, Alejandro
Cabezón, Arancha
Orozco, Gisela
Cobo, Tatiana
Miranda-Carus, Eugenia
López-Nevot, Miguel Angel
Vicario, José Luis
Martín-Mola, Emilio
Martín, Javier
Pascual-Salcedo, Dora
Filiación: [Balsa,A; Cobo,T;,Miranda-Carus,E; Martín-Mola,E] Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain.[Cabezón,A;Pascual-Salcedo,D] Sección de Inmunología, Hospital Universitario La Paz, Madrid, Spain. [Orozco,G;Martín,J] Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain. [López-Nevot,MA] Unidad de Inmunología, Hospital Universitario Virgen de las Nieves,Granada,Spain. [Vicario,JL] Unidad de Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain
Palabras clave : Secuencias de Aminoácidos
Artritis Reumatoide
Autoanticuerpos
Epítopos
Femenino
Marcadores Genéticos
Predisposición Genética a la Enfermedad
Antígenos HLA-DR
Cadenas HLA-DRB1
Humanos
Masculino
Mediana Edad
Péptidos Cíclicos
Conformación Proteica
Factor Reumatoide
MeSH: Medical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Rheumatoid
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Epitopes
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype::Genetic Markers
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens::HLA-DR beta-Chains::HLA-DRB1 Chains
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Macrocyclic Compounds::Peptides, Cyclic
Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Molecular Conformation::Protein Conformation
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Rheumatoid Factor
Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Amino Acid Sequence::Amino Acid Motifs
Fecha de publicación : 6-Apr-2010
Editorial : BioMed Central
Cita Bibliográfica: Balsa A, Cabezón A, Orozco G, Cobo T, Miranda-Carus E, López-Nevot MA, et al. Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor. Arthritis Res. Ther.; 12(2):R62
Abstract: INTRODUCTION The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF). METHODS We studied 408 patients (235 with RA, 173 non-RA) and 269 controls. ACPA, RF and HLA-DR typing were determined. RESULTS We found an increased frequency of HLA DRB1 alleles with the shared epitope (SE) in ACPA-positive RA. Inversely, HLA DRB1 alleles encoding DERAA sequences were more frequent in controls than in ACPA-positive RA, and a similar trend was found for HLA DR3. However, these results could not be confirmed after stratification for the presence of the SE, probably due to the relatively low number of patients. These data may suggest that the presence of these alleles may confer a protective role for ACPA-positive RA. In RA patients we observed association between SE alleles and ACPA titers in a dose-dependent effect. The presence of HLA DR3 or DERAA-encoding alleles was associated with markedly reduced ACPA levels. No association between RF titers and HLA DR3 or DERAA-encoding alleles was found. CONCLUSIONS HLA DRB1 alleles with the SE are associated with production of ACPA. DERAA-encoding HLA-DR alleles and HLA DR3 may be protective for ACPA-positive RA.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/634
Versión del editor : http://arthritis-research.com/content/12/2/R62
DOI: 10.1186/ar2975
ISSN : 1478-6362 (Online)
1478-6354 (Print)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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