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Título : Late pulmonary metastases of renal cell carcinoma immediatelyafter post-transplantation immunosuppressive treatment: a case report
Autor : Cozar, Jose M
Aptsiauri, Natalia
Tallada, Miguel
Garrido, Federico
Ruiz-Cabello, Francisco
Filiación: [Cozar,JM; Tallada,M] Servicio de Urología, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Aptsiauri,N; Garrido,F; Ruiz-Cabello,F] Servicio de Análisis Clínicos, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Palabras clave : Carcinoma de Células Renales
Metástasis de la Neoplasia
Trasplante de Riñón
MeSH: Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Renal Replacement Therapy::Kidney Transplantation
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma::Carcinoma, Renal Cell
Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Metastasis
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Urogenital Surgical Procedures::Urologic Surgical Procedures::Nephrectomy
Fecha de publicación : 18-Apr-2008
Editorial : BioMed Central
Cita Bibliográfica: Cózar JM, Aptsiauri N, Tallada M, Garrido F, Ruiz-Cabello F. Late pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case report. J Med Case Rep. 2008 Apr 18;2:111.
Abstract: INTRODUCTION We report a case of pulmonary metastatic recurrence of renal adenocarcinoma soon after radical nephrectomy that was followed by renal transplant and immunosuppressive medication. Increased risk of metastatic recurrence of renal cell carcinoma should be considered in the immediate post-transplant period when immunosuppressive medication is administered, even if nephrectomy had been performed many years earlier. CASE PRESENTATION In 1986 the patient demonstrated renal insufficiency secondary to mesangial glomerulonephritis. In 1992 he underwent left side radical nephrectomy with histopathological diagnosis of clear cell adenocarcinoma. Mesangial glomerulonephritis in the remaining right kidney progressed to end-stage renal failure. In October 2000 he received a kidney transplant from a cadaver and commenced immunosuppressive medication. Two months later, several nodules were found in his lungs, which were identified as metastases from the primary renal tumor that had been removed with the diseased kidney 8 years earlier. CONCLUSION Recurrence of renal cell carcinoma metastases points to tumor dormancy and reflects a misbalance between effective tumor immune surveillance and immune escape. This case demonstrates that a state of tumor dormancy can be interrupted soon after administration of immunosuppressant medication.
Descripción : Journal Article;
Versión del editor :
DOI: 10.1186/1752-1947-2-111
ISSN : 1752-1947 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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