Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/651
Title: Neural Correlates of the Severity of Cocaine, Heroin, Alcohol, MDMA and Cannabis Use in Polysubstance Abusers: A Resting-PET Brain Metabolism Study
Authors: Moreno-López, Laura
Stamatakis, Emmanuel A
Fernández-Serrano, Maria José
Gómez-Río, Manuel
Rodríguez-Fernández, Antonio
Pérez-García, Miguel
Verdejo-García, Antonio
metadata.dc.contributor.authoraffiliation: [Moreno-López,L; Pérez-García,M; Verdejo-García,A] Department of Personality, Evaluation and Psychological Treatment, University of Granada, Granada, Spain. [Stamatakis,EA] Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom. [Fernández-Serrano,MJ] Department of Psychology, University of Jaén, Jaén, Spain. [Gómez-Río,M; Rodríguez-Fernández,A] Service of Nuclear Medicine of the Hospital Virgen de las Nieves of Granada, Granada. [Pérez-García,M] Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, University of Granada, Granada, Spain. [Pérez-García,M; Verdejo-García,A] Institute of Neurosciences Federico Olóriz, University of Granada, Granada, Spain
Keywords: Trastornos relacionados con el uso de sustancias;Tomografía de Emisión de Positrones;Abuso de Marihuana;Dependencia de Heroína;Trastornos Relacionados con Cocaína;Alcoholismo;N-Metil-3,4-metilenodioxianfetamina;Conducta Adictiva;Encéfalo;Neuroimagen Funcional;Humanos;Vías Nerviosas
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Substance-Related Disorders
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, Emission-Computed::Positron-Emission Tomography
Medical Subject Headings::Diseases::Substance-Related Disorders::Marijuana Abuse
Medical Subject Headings::Diseases::Substance-Related Disorders::Opioid-Related Disorders::Heroin Dependence
Medical Subject Headings::Diseases::Substance-Related Disorders::Cocaine-Related Disorders
Medical Subject Headings::Diseases::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholism
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Impulsive Behavior::Compulsive Behavior::Behavior, Addictive
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Neuroimaging::Functional Neuroimaging
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Neuroimaging::Functional Neuroimaging
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Ethylamines::Phenethylamines::Amphetamines
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Ethylamines::Phenethylamines::Amphetamines::N-Methyl-3,4-methylenedioxyamphetamine
Medical Subject Headings::Anatomy::Nervous System::Neural Pathways
Issue Date: 29-Jun-2012
Publisher: Public Library of Science
Citation: Moreno-López L, Stamatakis EA, Fernández-Serrano MJ, Gómez-Río M, Rodríguez-Fernández A, Pérez-García M et al. Neural Correlates of the Severity of Cocaine, Heroin, Alcohol, MDMA and Cannabis Use in Polysubstance Abusers: A Resting-PET Brain Metabolism Study. PLoS One. 2012;7(6):e39830.
Abstract: INTRODUCTION Functional imaging studies of addiction following protracted abstinence have not been systematically conducted to look at the associations between severity of use of different drugs and brain dysfunction. Findings from such studies may be relevant to implement specific interventions for treatment. The aim of this study was to examine the association between resting-state regional brain metabolism (measured with 18F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and the severity of use of cocaine, heroin, alcohol, MDMA and cannabis in a sample of polysubstance users with prolonged abstinence from all drugs used. METHODS Our sample consisted of 49 polysubstance users enrolled in residential treatment. We conducted correlation analyses between estimates of use of cocaine, heroin, alcohol, MDMA and cannabis and brain metabolism (BM) (using Statistical Parametric Mapping voxel-based (VB) whole-brain analyses). In all correlation analyses conducted for each of the drugs we controlled for the co-abuse of the other drugs used. RESULTS The analysis showed significant negative correlations between severity of heroin, alcohol, MDMA and cannabis use and BM in the dorsolateral prefrontal cortex (DLPFC) and temporal cortex. Alcohol use was further associated with lower metabolism in frontal premotor cortex and putamen, and stimulants use with parietal cortex. CONCLUSIONS Duration of use of different drugs negatively correlated with overlapping regions in the DLPFC, whereas severity of cocaine, heroin and alcohol use selectively impact parietal, temporal, and frontal-premotor/basal ganglia regions respectively. The knowledge of these associations could be useful in the clinical practice since different brain alterations have been associated with different patterns of execution that may affect the rehabilitation of these patients.
URI: http://hdl.handle.net/10668/651
metadata.dc.relation.publisherversion: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039830
metadata.dc.identifier.doi: 0.1371/journal.pone.0039830
ISSN: 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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