Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/653
Título : Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus:AMultimodality-Based Diagnosis of Two Cases
Autor : Cobo, Fernando
Chamorro, Clara
Ramos, Francisco
Concha, Ángel
Filiación: [Cobo,F; Chamorro,C; Concha,A] Infectious Pathology Unit, Department of Pathology and Tissue and Tumor Bank, Hospital Universitario Virgen de las Nieves,Granada,Spain. [Ramos,F] Department of Pathology, Hospital de Torrecárdenas, Almería, Spain.
Palabras clave : Humanos
Linfoma Extranodal de Células NK-T
Neoplasias Nasales
Herpesvirus Humano 4
Diagnóstico
Diagnóstico Diferencial
Inmunocompetencia
Autopsia
MeSH: Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, T-Cell::Lymphoma, Extranodal NK-T
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Autopsy
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Otorhinolaryngologic Neoplasms::Nose Neoplasms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Organisms::Viruses::DNA Viruses::Herpesviridae::Gammaherpesvirinae::Lymphocryptovirus::Herpesvirus 4, Human
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnosis, Differential
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunocompetence
Fecha de publicación : 2009
Editorial : Hindawi Publishing Corporation.
Cita Bibliográfica: Cobo F, Chamorro C, Ramos F, Concha A. Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus: A Multimodality-Based Diagnosis of Two Cases. Scholarly Research Exchange, 2009 Article ID 963781, 5 pages doi:10.3814/2009/963781
Abstract: We report two cases of extranodal NK/T-cell lymphoma, nasal type, in immunocompetent patients without nasal cavity involvement. In the two cases, the initial presumptive diagnosis was tuberculosis and there was a rapid dissemination of the tumor with short survival after the hospital admittance. An autopsy was performed showing infiltration in several organs including lymph nodes and mesenteric and retroperitoneal fat. Histological sections showed an angiocentric and angiodestructive growth pattern and the immunophenotype was CD45+, CD3+ (cytoplasmic), as well as Granzyme B+ and EBV+. However, CD56 expression was only positive in a case in which the molecular study showed T-cell gene rearrangement with monoclonal appearance and associated with hemophagocytic syndrome. These cases represent rare examples of NK/T-cell lymphoma disseminated outside the nasal cavity highly aggressive that lead to the rapid death of the patients.
URI: http://hdl.handle.net/10668/653
Versión del editor : http://www.hindawi.com/archive/2009/963781/abs/
DOI: 10.3814/2009/963781
ISSN : 1687-8299 (Print)
1687-8302 (Online)
Appears in Collections:01- Artículos - Complejo Hospitalario Torrecárdenas
01- Artículos - Hospital Virgen de las Nieves

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