Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/665
Título : Exposure to Trihalomethanes through Different Water Uses and Birth Weight, Small for Gestational Age, and Preterm Delivery in Spain
Autor : Villanueva, Cristina M
Gracia-Lavedán, Esther
Ibarluzea, Jesús
Santa Marina, Loreto
Ballester, Ferran
Llop, Sabrina
Tardón, Adonina
Fernández, Mariana F
Freire, Carmen
Goñi, Fernando
Basagaña, Xavier
Kogevinas, Manolis
Grimalt, Joan O
Sunyer, Jordi
Filiación: [Villanueva,CM; Gracia-Lavedán,E; Basagaña,X; Kogevinas, M; Sunyer,J.] Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. [Villanueva,CM; Gracia-Lavedán,E; Basagaña,X; Kogevinas, M; Sunyer,J] IMIM (Hospital del Mar Research Institute), Barcelona, Spain. [Villanueva,C. M; Gracia-Lavedán,E; Basagaña,X; Kogevinas, M; Sunyer,J.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Ibarluzea,J; Santa Marina, L.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Ibarluzea,J; Santa Marina, L.] Subdirección de Salud Pública, Gipuzkoa, Spain. [Ballester, F.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Ballester, F.] Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. [Ballester, F.]Universitat de València, València, Spain. [Llop,S; Tardón, A.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Llop,S; Tardón, A.] Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. [Fernández,M.F; Freire,C.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Fernández,M.F; Freire,C.] Hospital Universitario San Cecilio, Universidad de Granada, Granada, Spain. [Goñi, F.] CIBER Epidemiología y Salud Pública (CIBERESP), Spain. [Goñi, F.] Laboratorio de Salud Pública, Gobierno Vasco, Spain. [Kogevinas, M.] National School of Public Health, Athens, Greece [Grimalt, J.O.] Institute of Environmental Assessment and Water Research (IDAEA), Centro Superior de Investigaciones Científicas (CSIC), Barcelona, Spain
Palabras clave : Contaminantes Químicos del Agua
Trihalometano
Estudios de Cohortes
Exposición a Riesgos Ambientales
Femeninos
Humanos
Recién Nacido de Bajo Peso
Recién nacido
Recién Nacido Pequeño para la Edad Gestacional
Modelos Logísticos
Modelos Teóricos
Embarazo
Nacimiento Prematuro
España
Adulto
birth weight
cohort study
disinfection by-products
epidemiology
low birth weight
newborn
premature birth
small for gestational age
trihalomethanes
water pollution
MeSH: Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Named Groups::Persons::Age Groups::Infant::Infant, Newborn::Infant, Low Birth Weight
Medical Subject Headings::Named Groups::Persons::Age Groups::Infant::Infant, Newborn
Medical Subject Headings::Named Groups::Persons::Age Groups::Infant::Infant, Newborn::Infant, Low Birth Weight::Infant, Small for Gestational Age
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy
Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Obstetric Labor Complications::Obstetric Labor, Premature::Premature Birth
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Halogenated::Trihalomethanes
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Water Pollutants::Water Pollutants, Chemical
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Fecha de publicación : Dec-2011
Editorial : National Institute of Enviromental Health-Science (NIEHS)
Cita Bibliográfica: Villanueva CM, Gracia-Lavedán E, Ibarluzea J, Santa Marina L, Ballester F, Llop S, et al. Exposure to trihalomethanes through different water uses and birth weight, small for gestational age, and preterm delivery in Spain. Environ. Health Perspect.. 2011 Dec; 119(12):1824-30
Abstract: BACKGROUND Evidence associating exposure to water disinfection by-products with reduced birth weight and altered duration of gestation remains inconclusive. OBJECTIVE We assessed exposure to trihalomethanes (THMs) during pregnancy through different water uses and evaluated the association with birth weight, small for gestational age (SGA), low birth weight (LBW), and preterm delivery. METHODS Mother-child cohorts set up in five Spanish areas during the years 2000-2008 contributed data on water ingestion, showering, bathing, and swimming in pools. We ascertained residential THM levels during pregnancy periods through ad hoc sampling campaigns (828 measurements) and regulatory data (264 measurements), which were modeled and combined with personal water use and uptake factors to estimate personal uptake. We defined outcomes following standard definitions and included 2,158 newborns in the analysis. RESULTS Median residential THM ranged from 5.9 μg/L (Valencia) to 114.7 μg/L (Sabadell), and speciation differed across areas. We estimated that 89% of residential chloroform and 96% of brominated THM uptakes were from showering/bathing. The estimated change of birth weight for a 10% increase in residential uptake was -0.45 g (95% confidence interval: -1.36, 0.45 g) for chloroform and 0.16 g (-1.38, 1.70 g) for brominated THMs. Overall, THMs were not associated with SGA, LBW, or preterm delivery. CONCLUSIONS Despite the high THM levels in some areas and the extensive exposure assessment, results suggest that residential THM exposure during pregnancy driven by inhalation and dermal contact routes is not associated with birth weight, SGA, LBW, or preterm delivery in Spain.
Descripción : Reproduced with permission from Environmental Health Perspectives. Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/665
Versión del editor : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261969/?report=abstract
DOI: 10.1289/ehp.1002425
ISSN : 1552-9924 (Online)
0091-6765 (Print)
Appears in Collections:01- Artículos - Hospital San Cecilio

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