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Title: Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism
Authors: Asúa, Teresa
Bilbao, Ainhoa
Gorriti, Miguel Angel
Lopez-Moreno, Jose Antonio
Alvarez, Maria del Mar
Navarro, Miguel
Rodríguez de Fonseca, Fernando
Perez-Castillo, Ana
Santos, Angel
metadata.dc.contributor.authoraffiliation: [Asúa, T; Álvarez, MM; Santos, A] Departamento de Bioquímica y Biología Molecular, Universidad Complutense de Madrid, Madrid, Spain. [Gorriti, MA; Lopez-Moreno, JA; Navarro, M: Rodriguez de Fonseca, F] Facultad de Medicina, Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Perez-Castillo, A] Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Cientificas-Universidad Autonoma de Madrid, Madrid, Spain. [Bilbao,A; Rodriguez de Fonseca, F] Fundación Instituto Mediterráneo para el Avance de la Biomedicina y la Investigación, Hospital Carlos Haya, Málaga, Spain.
Keywords: Animales;Animales recién nacidos;Ganglios basales;Conducta animal;Cerebelo;Hipotiroidismo congénito;Evaluación preclínica de medicamentos;Endocannabinoides;Femenino;Hipercinesia;Actividad Motora;Embarazo;ARN mensajero;Ratas;Ratas Wistar;Receptor cannabinoide CB1;Triyodotironina
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Newborn
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Basal Ganglia
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavior, Animal
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Rhombencephalon::Metencephalon::Cerebellum
Medical Subject Headings::Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Dwarfism::Congenital Hypothyroidism
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Drug Evaluation, Preclinical
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Dyskinesias::Hyperkinesis
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid::Receptor, Cannabinoid, CB1
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Thyroid Hormones::Thyronines::Triiodothyronine
Medical Subject Headings::Organisms::Eukaryota::Animals
Issue Date: May-2008
Publisher: Endocrine Society
Citation: Asúa T, Bilbao A, Gorriti MA, Lopez-Moreno JA, Alvarez MM, Navarro M, et al. Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism. Endocrinology. 2008 May; 149(5):2657-66
Abstract: Alterations in motor functions are well-characterized features observed in humans and experimental animals subjected to thyroid hormone dysfunctions during development. Here we show that congenitally hypothyroid rats display hyperactivity in the adult life. This phenotype was associated with a decreased content of cannabinoid receptor type 1 (CB(1)) mRNA in the striatum and a reduction in the number of binding sites in both striatum and projection areas. These findings suggest that hyperactivity may be the consequence of a thyroid hormone deficiency-induced removal of the endocannabinoid tone, normally acting as a brake for hyperactivity at the basal ganglia. In agreement with the decrease in CB(1) receptor gene expression, a lower cannabinoid response, measured by biochemical, genetic and behavioral parameters, was observed in the hypothyroid animals. Finally, both CB(1) receptor gene expression and the biochemical and behavioral dysfunctions found in the hypothyroid animals were improved after a thyroid hormone replacement treatment. Thus, the present study suggests that impairment in the endocannabinoid system can underlay the hyperactive phenotype associated with hypothyroidism.
Description: Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1210/en.2007-1586
ISSN: 1945-7170 (Online)
0013-7227 (Print)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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