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Title: Decreased STAMP2 expression in association with visceral adipose tissue dysfunction.
Authors: Moreno-Navarrete, José María
Ortega, Francisco
Serrano, Marta
Pérez-Pérez, Rafael
Sabater, Mònica
Ricart, Wifredo
Tinahones Madueño, Francisco José
Peral, Belén
Fernández-Real, José Manuel
metadata.dc.contributor.authoraffiliation: [Moreno-Navarrete,JM; Ortega,F; Serrano,M; Sabater,M; Ricart,W; Fernández-Real,JM] Service of Diabetes, Endocrinology, and Nutrition, Institut d'Investigació Biomèdica de Girona, CIBEROBN and Instituto de Salud Carlos III, Girona, Spain. [Pérez-Pérez,R; Peral,B] Instituto de Investigaciones Biomédicas “Alberto Sols” (IIB), Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain. [Tinahones Madueño,FJ] Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria de Málaga, CIBEROBN Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Málaga, Spain.
Keywords: Membrane Proteins;Thiazolidinediones;Tumor Necrosis Factor-alpha;rosiglitazone;Oxidoreductases;STEAP4 protein, human;Hypoglycemic Agents
metadata.dc.subject.mesh: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents
Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Abdominal Fat::Intra-Abdominal Fat
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases
Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Subcutaneous Fat
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiazoles::Thiazolidinediones
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha
Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Adipocytes
Issue Date: Nov-2011
Publisher: Endocrine Society
Citation: Moreno-Navarrete JM, Ortega F, Serrano M, Pérez-Pérez R, Sabater M, Ricart W, et al. Decreased STAMP2 expression in association with visceral adipose tissue dysfunction. J. Clin. Endocrinol. Metab.. 2011.96(11):E1816-25
Abstract: CONTEXT Six-transmembrane protein of prostate 2 (STAMP2) is a counter-regulator of inflammation and insulin resistance according to findings in mice. However, there have been contradictory reports in humans. OBJECTIVE We aimed to explore STAMP2 in association with inflammatory and metabolic status of human obesity. DESIGN, PATIENTS, AND METHODS STAMP2 gene expression was analyzed in adipose tissue samples (171 visceral and 67 sc depots) and during human preadipocyte differentiation. Human adipocytes were treated with macrophage-conditioned medium, TNF-α, and rosiglitazone. RESULTS In visceral adipose tissue, STAMP2 gene expression was significantly decreased in obese subjects, mainly in obese subjects with type 2 diabetes. STAMP2 gene expression and protein were significantly and inversely associated with obesity phenotype measures (body mass index, waist, hip, and fat mass) and obesity-associated metabolic disturbances (systolic blood pressure and fasting glucose). In addition, STAMP2 gene expression was positively associated with lipogenic (FASN, ACC1, SREBP1, THRSP14, TRα, and TRα1), CAV1, IRS1, GLUT4, and CD206 gene expression. In sc adipose tissue, STAMP2 gene expression was not associated with metabolic parameters. In both fat depots, STAMP2 gene expression in stromovascular cells was significantly higher than in mature adipocytes. STAMP2 gene expression was significantly increased during the differentiation process in parallel to adipogenic genes, being increased in preadipocytes derived from lean subjects. Macrophage-conditioned medium (25%) and TNF-α (100 ng/ml) administration increased whereas rosiglitazone (2 μM) decreased significantly STAMP2 gene expression in human differentiated adipocytes. CONCLUSIONS Decreased STAMP2 expression (mRNA and protein) might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes.
Description: Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1210/jc.2011-0310
ISSN: 1945-7197 (Online)
0021-972X (Print)
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria

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