Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/810
Title: Thin healthy women have a similar low bone mass to women with anorexia nervosa.
Authors: Fernández-García, Diego José
Rodríguez, M
García Alemán, Jorge
García-Almeida, José Manuel
Picón César, María José
Fernández-Aranda, F
Tinahones Madueño, Francisco José
metadata.dc.contributor.authoraffiliation: [Fernández-García,DJ; García-Alemán,J; García-Almeida,JM; Picón César,MJ; Tinahones Madueño,FJ] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Rodríguez,M] Servicio de Reumatología, Hospital Carlos Haya, Málaga, Spain. [Fernández-Aranda,F] Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain.
Keywords: Bone mineral density;Estrógenos;Anorexia nerviosa;Índice de masa corporal;Peso corporal;Densidad ósea;Huesos;Hormona de Crecimiento Humana;Leptina;Tamaño de los Órganos;Valores de referencia;Delgadez;Adolescente;Adulto;Edad de Inicio;Huesos;Diagnostic and Statistical Manual of Mental Disorders;Humanos
metadata.dc.subject.mesh: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Age Factors::Age of Onset
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Eating Disorders::Anorexia Nervosa
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Body Weight
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density
Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones
Medical Subject Headings::Information Science::Information Science::Information Services::Documentation::Vocabulary, Controlled::Diagnostic and Statistical Manual of Mental Disorders
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Estrogens
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Growth Hormone::Human Growth Hormone
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Leptin
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Organ Size
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Weights and Measures::Reference Values
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Thinness
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young Adult
Medical Subject Headings::Named Groups::Persons::Age Groups::Adolescent
Issue Date: Sep-2009
Publisher: Cambridge University Press
Citation: Fernández-García D, Rodríguez M, García Alemán J, García-Almeida JM, Picón César MJ, Fernández-Aranda F, et al. Thin healthy women have a similar low bone mass to women with anorexia nervosa. Br. J. Nutr.. 2009 ; 102(5):709-14
Abstract: An association between anorexia nerviosa (AN) and low bone mass has been demonstrated. Bone loss associated with AN involves hormonal and nutritional impairments, though their exact contribution is not clearly established. We compared bone mass in AN patients with women of similar weight with no criteria for AN, and a third group of healthy, normal-weight, age-matched women. The study included forty-eight patients with AN, twenty-two healthy eumenorrhoeic women with low weight (LW group; BMI < 18.5 kg/m2) and twenty healthy women with BMI >18.5 kg/m2 (control group), all of similar age. We measured lean body mass, percentage fat mass, total bone mineral content (BMC) and bone mineral density in lumbar spine (BMD LS) and in total (tBMD). We measured anthropometric parameters, leptin and growth hormone. The control group had greater tBMD and BMD LS than the other groups, with no differences between the AN and LW groups. No differences were found in tBMD, BMD LS and total BMC between the restrictive (n 25) and binge-purge type (n 23) in AN patients. In AN, minimum weight (P = 0.002) and percentage fat mass (P = 0.02) explained BMD LS variation (r2 0.48) and minimum weight (r2 0.42; P = 0.002) for tBMD in stepwise regression analyses. In the LW group, BMI explained BMD LS (r2 0.72; P = 0.01) and tBMD (r2 0.57; P = 0.04). We concluded that patients with AN had similar BMD to healthy thin women. Anthropometric parameters could contribute more significantly than oestrogen deficiency in the achievement of peak bone mass in AN patients.
Description: Journal Article;
URI: http://hdl.handle.net/10668/810
metadata.dc.relation.publisherversion: http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=6112524
metadata.dc.identifier.doi: 10.1017/S0007114509274733
ISSN: 1475-2662 (Online)
0007-1145 (Print)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Virgen de la Victoria

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