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Title: Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?
Authors: Verge González, Carmen
Lucena González, María Isabel
López-Torres, Enrique
Puche-García, María José
Fraga, Enrique
Romero-Gómez, Manuel
Andrade Bellido, Raúl Jesús
metadata.dc.contributor.authoraffiliation: [Verge González,C; Lucena González,MI; López-Torres,E; Puche-García,MJ] Clinical Pharmacology Service, Hospital Universitario Virgen de la Victoria, School of Medicine, Málaga, Spain. [Fraga,E] Gastroenterology Service, University Hospital Reina Sofia, Córdoba, Spain. [Romero-Gómez,M] Gastroenterology Service, University Hospital Virgen de Valme, Sevilla, Spain. [Andrade Bellido,RJ] Liver Unit, Department of Gastroenterology, Hospital Universitario Virgen de la Victoria, Málaga, Spain.
Keywords: Calcium carbimide;Hepatotoxicity;Disuasivos de Alcohol;Cianamida;Disulfiram;Interacciones de Drogas;Hígado;Enfermedad Hepática Inducida por Drogas;Femenino;Humanos;Masculino;Mediana Edad;Adulto
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Alcohol Deterrents
Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Nitrogen Compounds::Hydrogen Cyanide::Cyanides::Cyanamide
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Carbamates::Thiocarbamates::Ditiocarb::Disulfiram
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Pharmacological Processes::Drug Interactions
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Drug-Induced Liver Injury
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Issue Date: 21-Aug-2006
Publisher: Baishideng Publishing Group Co. Limited
Citation: Verge González C, Lucena González MI, López-Torres E, Puche-García MJ, Fraga E, Romero-Gómez M, et al. Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs? World J. Gastroenterol.. 2006;12(31):5078-80
Abstract: Disulfiram and calcium carbimide are two alcohol deterrants widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here, we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when prescribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed.
Description: Case Reports; Journal Article; Research Support, Non-U.S. Gov't;
ISSN: 2219-2840 (Online)
1007-9327 (Print)
Appears in Collections:01- Artículos - Hospital de Valme
01- Artículos - Hospital Reina Sofía
01- Artículos - Hospital Virgen de la Victoria

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