Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/816
Título : Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.
Autor : Liu, Kui
Li, Quan-Zhen
Delgado-Vega, Angelica M
Abelson, Anna-Karin
Sánchez, Elena
Kelly, Jennifer A
Li, Li
Liu, Yang
Zhou, Jinchun
Yan, Mei
Ye, Qiu
Liu, Shenxi
Xie, Chun
Zhou, Xin J
Chung, Sharon A
Pons-Estel, Bernardo
Witte, Torsten
Ramón, Enrique de
Bae, Sang-Cheol
Barizzone, Nadia
Sebastiani, Gian Domenico
Merrill, Joan T
Gregersen, Peter K
Gilkeson, Gary G
Kimberly, Robert P
Vyse, Timothy J
Kim, Il
D'Alfonso, Sandra
Martin, Javier
Harley, John B
Criswell, Lindsey A
Wakeland, Edward K
Alarcón-Riquelme, Marta E
Mohan, Chandra
Danieli, Maria Giovanna
Galeazzi, Mauro
Querini, Patrizia Rovere
Migliaresi, Sergio
Scherbarth, Hugo R
Lopez, Jorge A
Motta, Estela L
Gamron, Susana
Drenkard, Cristina
Menso, Emilia
Allievi, Alberto
Tate, Guillermo A
Presas, José L
Palatnik, Simon A
Abdala, Marcelo
Bearzotti, Mariela
Alvarellos, Alejandro
Caeiro, Francisco
Bertoli, Ana
Paira, Sergio
Roverano, Susana
Graf, Cesar E
Bertero, Estela
Caprarulo, Cesar
Buchanan, Griselda
Guillerón, Carolina
Grimaudo, Sebastian
Manni, Jorge
Catoggio, Luis J
Soriano, Enrique R
Santos, Carlos D
Prigione, Cristina
Ramos, Fernando A
Navarro, Sandra M
Berbotto, Guillermo A
Jorfen, Marisa
Romero, Elisa J
Garcia, Mercedes A
Marcos, Juan C
Marcos, Ana I
Perandones, Carlos E
Eimon, Alicia
Battagliotti, Cristina G
Armadi-Simab, K
Gross, Wolfgang L
Gromnica-Ihle, Erika
Peter, Hans-Hartmut
Manger, Karin
Schnarr, Sebastian
Zeidler, Henning
Schmidt, Reinhold E
Ortego, Norberto
Callejas, José L
Jiménez-Alonso, Juan
Sabio, Mario
Sánchez-Román, Julio
Garcia-Hernandez, Francisco J
Camps, Mayte
López-Nevot, Miguel Angel
González-Escribano, Maria F
Harley, John H
Kimberly, Robert
Criswell, Lindsey
Langefeld, Carl
Tsao, Betty
Jacob, Chaim
Filiación: [Li, K; Li, Q; Liu,Y; Zhou, J; Yan, M; Ye, Q; Liu, S; Xie, C; Zhou, X; Wakeland, EK; Mohan, C] Department of Immunology and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [Delgado-Vega ,AM; Abelson, A-K; Alarcón-Riquelme, ME] Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. [Sánchez, E; Martin, J] Instituto de Biomedicina y Parasitología López Neyra, CSIC, Granada, Spain. [Kelli, JA; Merrill, JT; Harley, JB; Alarcón-Riquelme, ME] Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA. [Chung, A; Criswell, LA] UCSF, San Francisco, California, USA. [Pons-Estel, P] Sanatorio Parque, Rosario, Argentina. [Witte,T].Hannover Medical School, Hannover, Germany. [Ramón, E de] Servicio de Medicina Interna, Hospital Carlos Haya, Malaga, Spain. [Bae, S-C; Kim, I] Department of Rheumatology, Hospital for Rheumatic Diseases, Hanyang University, Seoul, Republic of Korea. [Barizzone, N; D’Alonso, S] Department of Medical Sciences and IRCAD, University of Eastern Piedmont, Novara, Italy. [Sebastiani, GD] U.O.C. di Reumatologia Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy. [Gregersen, PK] Feinstein Institute for Medical Research, Long Island Jewish Health System, Manhasset, New York, USA. [Gilkeson, GG] Medical University of South Carolina, Charleston, South Carolina, USA. [Kimberly, RP] University of Alabama at Birmingham, Birmingham, Alabama, USA. [Vyse,TJ] Section of Medical Genetics and Rheumatology, Hammersmith Hospital, Imperial College London, London, United Kingdom. [Danieli, MD; Galeazzi, M; Querini, PR; Migliaresi, S] Italian Collaborative Group. [Scherbarth, HR; Lopez, JA; Motta, EL; Alende, O; Gamron, S; Drenkard, C; Menso, E; Allievi, A; Tate, GA; Presas, JL; Palatnic, SA; Abdala, M; Bearzotti, M; Alvarellos, A; Caeiro, F; Bertoli, A; Paira, S; Roverano, S; Graf, CE; Bertero, E; Caprarulo, C; Buchanan, G; Guillerón, C; Grimaudo, S; Manni, J; Catoggio ,LJ; Soriano, ER; Santos, CD; Prigione, C; Ramos, FA; Navarro, SM; Berbotto, GA; Jorfen, M; Romero, EJ; Garcia, MA; Marcos, JC; Marcos, AI; Perandones, CE; Eimon, A; Battagliotti, CG] Argentine Collaborative Group. [Armadi-Simab, K; Gross, WL; Gromnica-Ihle, E; Hans-Hartmut, P; Manger, K; Schnarr, S; Zeidler, H; Schmidt, RE] German Collaborative Group. [Ortega, N; Callejas, JL; Jiménez-Alonso, J; Sabio, M; Sánchez-Román, J; Garcia-Hernandez, FJ; Camps, M; López-Nevot, MA; González-Escribano, MF] Spanish Collaborative Group. [Harley, JH; Alarcon-Riquelme, M; Criswell, L; Langefeld, C; Tsao, B; Jacob, C] The SLEGEN consortium.
Grupo de Investigación: The Profile Study Group
The Italian Collaborative Group
The German Collaborative Group
The Spanish Collaborative Group
The Argentinian Collaborative Group
The SLEGEN Consortium
Palabras clave : Animales
Secuencia de Bases
DNA
Modelos animales de enfermedad
Femenino
Perfiles de expresión génica
Membrana basal glomerular
Humanos
Calicreínas
Lupus eritematoso sistémico
Nefritis lúpica
Ratones
Ratones consanguíneos BALB C
Ratones consanguíneos DBA
Datos de Secuencia Molecular
Análisis de secuencia de alineamiento de oligonucleótidos
Polimorfismo genético
Homología de Secuencia de Ácido Nucleico
Especificidad de la Especie
MeSH: Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Base Sequence
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling
Medical Subject Headings::Anatomy::Cells::Cellular Structures::Extracellular Space::Extracellular Matrix::Glomerular Basement Membrane
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Blood Coagulation Factors::Kallikreins
Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Lupus Erythematosus, Systemic
Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Lupus Erythematosus, Systemic::Lupus Nephritis
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred BALB C
Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred DBA
Medical Subject Headings::Information Science::Information Science::Information Services::Documentation::Molecular Sequence Data
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Molecular Probe Techniques::Oligonucleotide Array Sequence Analysis
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Sequence Homology::Sequence Homology, Nucleic Acid
Medical Subject Headings::Phenomena and Processes::Biological Phenomena::Species Specificity
Medical Subject Headings::Organisms::Eukaryota::Animals
Fecha de publicación : Apr-2009
Editorial : American Society for Clinical Investigation
Cita Bibliográfica: Liu K, Li QZ, Delgado-Vega AM, Abelson AK, Sánchez E, Kelly JA, et al. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. J. Clin. Invest.. 2009 Apr; 119(4):911-23
Abstract: Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred mouse strains differ in susceptibility to anti-GBM antibody-induced and spontaneous lupus nephritis. This study sought to clarify the genetic and molecular factors that maybe responsible for enhanced immune-mediated renal disease in these models. When the kidneys of 3 mouse strains sensitive to anti-GBM antibody-induced nephritis were compared with those of 2 control strains using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene family,which encodes serine esterases. Mouse strains that upregulated renal and urinary kallikreins exhibited less evidence of disease. Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced nephritis. In addition, nephritis-sensitive mouse strains had kallikrein haplotypes that were distinct from those of control strains, including several regulatory polymorphisms,some of which were associated with functional consequences. Indeed, increased susceptibility to anti-GBM antibody-induced nephritis and spontaneous lupus nephritis was achieved by breeding mice with a genetic interval harboring the kallikrein genes onto a disease-resistant background. Finally, both human SLE and spontaneous lupus nephritis were found to be associated with kallikrein genes, particularly KLK1 and the KLK3 promoter, when DNA SNPs from independent cohorts of SLE patients and controls were compared. Collectively, these studies suggest that kallikreins are protective disease-associated genes in anti-GBM antibody-induced nephritis and lupus.
Descripción : Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/816
Versión del editor : http://www.jci.org/articles/view/36728
DOI: 10.1172/JCI36728
ISSN : 1558-8238 (Online)
0021-9738 (Print)
Appears in Collections:01- Artículos - Hospital Regional de Málaga

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