Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/817
Título : Differential cognitive impairment for diverse forms of multiple sclerosis.
Autor : Gonzalez-Rosa, Javier J
Vazquez-Marrufo, Manuel
Vaquero, Encarnacion
Duque, Pablo
Borges, Monica
Gamero, Miguel A
Gomez, Carlos M
Izquierdo, Guillermo
Filiación: [Gonzalez-Rosa,JJ; Duque,P; Borges,M; Gamero,MA; Izquierdo,G] Multiple Sclerosis Unit,Virgen Macarena Hospital,Seville, Spain. [Gonzalez-Rosa,JJ; Vazquez-Marrufo,M; Vaquero,E; Gomez,CM] Laboratory of Psychophysiology,Departament of Experimental Psychology,University of Seville, Spain
Palabras clave : Conducta
Adulto
Trastornos del Conocimiento
Señales
Femenino
Humanos
Masculino
Esclerosis Múltiple
Esclerosis Múltiple Recurrente-Remitente
Electroencefalografía
MeSH: Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Behavior Control
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Delirium, Dementia, Amnestic, Cognitive Disorders::Cognition Disorders
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Cues
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Neurological::Electroencephalography
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Diseases::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Relapsing-Remitting
Fecha de publicación : 19-May-2006
Editorial : BMC
Cita Bibliográfica: Gonzalez-Rosa JJ, Vazquez-Marrufo M, Vaquero E, Duque P, Borges M, Gamero MA, et al. Differential cognitive impairment for diverse forms of multiple sclerosis. BMC Neurosci; 2006, 7:39
Abstract: BACKGROUND Cognitive impairment is a common feature in multiple sclerosis (MS) patients and occurs in 60% of all cases. Unfortunately, neurological examination does not always agree with the neuropsychological evaluation in determining the cognitive profile of the patient. On the other hand, psychophysiological techniques such as event-related potentials (ERPs) can help in evaluating cognitive impairment in different pathologies. Behavioural responses and EEG signals were recorded during the experiment in three experimental groups: 1) a relapsing-remitting group (RRMS), 2) a benign multiple sclerosis group (BMS) and 3) a Control group. The paradigm employed was a spatial attention task with central cues (Posner experiment). The main aim was to observe the differences in the performance (behavioural variables) and in the latency and amplitude of the ERP components among these groups. RESULTS Our data indicate that both MS groups showed poorer task performance (longer reaction times and lower percentage of correct responses), a latency delay for the N1 and P300 component, and a different amplitude for the frontal N1. Moreover, the deficit in the BMS group, indexed by behavioural and pyschophysiological variables, was more pronounced compared to the RRMS group. CONCLUSION The present results suggest a cognitive impairment in the information processing in all of these patients. Comparing both pathological groups, cognitive impairment was more accentuated in the BMS group compared to the RMSS group. This suggests a silent deterioration of cognitive skills for the BMS that is not usually treated with pharmacological or neuropsychological therapy.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/817
Versión del editor : http://www.biomedcentral.com/1471-2202/7/39
DOI: 10.1186/1471-2202-7-39
ISSN : 1471-2202 (Online)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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