Please use this identifier to cite or link to this item:
Title: Adherence to interferon β-1b treatment in patients with multiple sclerosis in Spain
Authors: Fernández, Oscar
Agüera, Eduardo
Izquierdo, Guillermo
Millán-Pascual, Jorge
Ramió I Torrentà, Lluis
Oliva, Pedro
Argente, Joaquin
Berdei, Yasmina
Soler, Jose Maria
Carmona, Olga
Errea, Jose Maria
Farrés, Jordi
metadata.dc.contributor.authoraffiliation: [Fernández,O] Hospital Universitario Carlos Haya de Málaga, Málaga, Spain. [Agüera,E] Hospital Universitario Reina Sofía Córdoba, Spain. [Izquierdo,G] Hospital Virgen de la Macarena, Sevilla, Spain. [Millán-Pascual,J] Hospital La Mancha Centro, Alcázar de San Juan, Spain. [Ramió i Torrentà,Ll] Hospital Josep Trueta, Girona, Spain. [Oliva,P] HUC de Asturias, Oviedo, Spain. [Argente,J] Hospital Puerta del Mar, Cádiz, Spain. [Berdei,Y] Hospital de Salamanca, Salamanca, Spain. [Soler,JM] Hospital de Sant Joan de Déu de Manresa, Manresa, Spain. [Carmona,O] Hospital de Figueres, Figueres, Spain. [Errea,JM] Hospital de Figueres, Figueres, Spain. [Farrés,J] Bayer Hispania, Barcelona, Spain. Group on Adherence to IFNb-1b in Spain
Keywords: Interferon beta-1b;Humanos;Mediana Edad;Esclerosis Múltiple;Cooperación del Paciente;España
metadata.dc.subject.mesh: Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interferons::Interferon Type I::Interferon-beta
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Delivery of Health Care::Attitude to Health::Patient Acceptance of Health Care::Patient Compliance
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Issue Date: 16-May-2012
Publisher: Public Library of Science
Citation: Fernández O, Agüera E, Izquierdo G, Millán-Pascual J, Ramió I Torrentà Ll, Oliva P, et al. Adherence to interferon β-1b treatment in patients with multiple sclerosis in Spain. PLoS ONE. 2012; 7(5):e35600
Abstract: BACKGROUND Adherence to interferon β-1b (INFβ-1b) therapy is essential to maximize the beneficial effects of treatment in multiple sclerosis (MS). For that reason, the main objectives of this study are to assess adherence to INFβ-1b in patients suffering from MS in Spain, and to identify the factors responsible for adherence in routine clinical practice. METHODOLOGY/PRINCIPAL FINDINGS This was an observational, retrospective, cross-sectional study including 120 Spanish patients with MS under INFβ-1b treatment. Therapeutic adherence was assessed with Morisky-Green test and with the percentage of doses received. The proportion of adherent patients assessed by Morisky-Green test was 68.3%, being indicative of poor adherence. Nevertheless, the percentage of doses received, which was based on the number of injected medication, was 94.3%. The main reason for missing INFβ-1b injections was forgetting some of the administrations (64%). Therefore, interventions that diminish forgetfulness might have a positive effect in the proportion of adherent patients and in the percentage of doses received. In addition, age and comorbidities had a significant effect in the number of doses injected per month, and should be considered in the management of adherence in MS patients. CONCLUSION/SIGNIFICANCE Among all the available methods for assessing adherence, the overall consumption of the intended dose has to be considered when addressing adherence.
Description: Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1371/journal.pone.0035600
ISSN: 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Puerta del Mar
01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Reina Sofía
01- Artículos - Hospital Virgen Macarena

Files in This Item:
File Description SizeFormat 
FernandezO_AdherenceToInterferon.pdfArtículo publicado85,2 kBAdobe PDFView/Open
FernandezO_AdherenceToInterferonFormalCorrection.pdfCorrección formal. Error en los autores231,96 kBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons