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Título : Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels.
Autor : Tinahones, Francisco José
Coín-Aragüez, Leticia
Mayas, María Dolores
García-Fuentes, Eduardo
Hurtado-Del-Pozo, Carmen
Vendrell, Joan
Cardona, Fernando
Calvo, Rosa-María
Obregón, María-Jesus
El Bekay, Rajaa
Filiación: [Tinahones,FJ; Coín-Aragüez,L; Mayas,MD; García-Fuentes,E; Cardona,F; El Bekay,R] CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Madrid, Spain. [Tinahones,FJ; Coín-Aragüez,L; Mayas,MD; García-Fuentes,E; El Bekay,R] Laboratorio de Investigación Biomédica, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Tinahones,FJ; Cardona,F] Servicio de Endocrinología, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Hurtado-Del-Pozo,C; Calvo,RM; Obregón,MJ] Instituto de Investigaciones Biomédicas (IIBM, CSIC-UAM]), Madrid, Spain. [Vendrell,J] CIBERDEM. University Hospital of Tarragona Joan XXIII. IISPV, Rovira i Virgili University, Tarragona, Spain.
Palabras clave : Inductores de la Angiogénesis
Marcadores Biológicos
Expresión Génica
Resistencia a la Insulina
Neovascularización Fisiológica
Obesidad Mórbida
Grasa Subcutánea
Factor A de Crecimiento Endotelial Vascular
Tejido Adiposo
MeSH: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Growth Substances::Angiogenesis Modulating Agents::Angiogenesis Inducing Agents
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance::Insulin Resistance
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Metalloproteases
Medical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Cardiovascular Physiological Processes::Neovascularization, Physiologic
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Obesity, Morbid
Medical Subject Headings::Anatomy::Body Regions::Torso::Abdomen::Abdominal Cavity::Peritoneum::Omentum
Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Subcutaneous Fat
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Angiogenic Proteins::Vascular Endothelial Growth Factors::Vascular Endothelial Growth Factor A
Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue
Fecha de publicación : Apr-2012
Editorial : BioMed Central
Cita Bibliográfica: Tinahones FJ, Coín-Aragüez L, Mayas MD, García-Fuentes E, Hurtado-del-Pozo C, Vendrell J, et al. Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels. BMC Physiol. 2012; 12:4
Abstract: BACKGROUND The expansion of adipose tissue is linked to the development of its vasculature, which appears to have the potential to regulate the onset of obesity. However, at present, there are no studies highlighting the relationship between human adipose tissue angiogenesis and obesity-associated insulin resistance (IR). RESULTS Our aim was to analyze and compare angiogenic factor expression levels in both subcutaneous (SC) and omentum (OM) adipose tissues from morbidly obese patients (n = 26) with low (OB/L-IR) (healthy obese) and high (OB/H-IR) degrees of IR, and lean controls (n = 17). Another objective was to examine angiogenic factor correlations with obesity and IR.Here we found that VEGF-A was the isoform with higher expression in both OM and SC adipose tissues, and was up-regulated 3-fold, together with MMP9 in OB/L-IR as compared to leans. This up-regulation decreased by 23% in OB/-H-IR compared to OB/L-IR. On the contrary, VEGF-B, VEGF-C and VEGF-D, together with MMP15 was down-regulated in both OB/H-IR and OB/L-IR compared to lean patients. Moreover, MMP9 correlated positively and VEGF-C, VEGF-D and MMP15 correlated negatively with HOMA-IR, in both SC and OM. CONCLUSION We hereby propose that the alteration in MMP15, VEGF-B, VEGF-C and VEGF-D gene expression may be caused by one of the relevant adipose tissue processes related to the development of IR, and the up-regulation of VEGF-A in adipose tissue could have a relationship with the prevention of this pathology.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
Versión del editor :
DOI: 10.1186/1472-6793-12-4
ISSN : 1472-6793 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria

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