Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/871
Título : Human Papillomavirus (HPV) Type Distribution in Females with Abnormal Cervical Cytology. A Correlation with Histological Study
Autor : Cobo, Fernando
Concha, Angel
Ortiz, Marta
Filiación: [Cobo.F; Concha,A] Infectious Pathology Unit, Department of Pathology, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Ortiz,M] Centro Nacional de Microbiología, Madrid, Spain.
Palabras clave : Colposcopía
ADN Viral
Frotis Vaginal
Infecciones Tumorales por Virus
Reacción en Cadena de la Polimerasa
Femenino
MeSH: Medical Subject Headings::Organisms::Viruses::DNA Viruses::Papillomaviridae
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Obstetrical and Gynecological::Colposcopy
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Viral
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Vaginal Smears
Medical Subject Headings::Diseases::Virus Diseases::Tumor Virus Infections
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction
Medical Subject Headings::Check Tags::Female
Fecha de publicación : 4-Sep-2009
Editorial : Bentham Open
Cita Bibliográfica: Cobo F, Concha A, Ortiz M. Human Papillomavirus (HPV) Type Distribution in Females with Abnormal Cervical Cytology. A Correlation with Histological Study. Open Virol J. 2009; 3:60-6
Abstract: The aim of this study was to determine human papillomavirus (HPV) types distribution in cervical preneoplasic lesions in a Southern Spanish population and their relationship between HPV type and grade of histopathological abnormality. Finally, 232 cervical samples from 135 women with previous cytological abnormalities were included in this study. Colposcopy studies and biopsies were performed. Haematoxylin-eosin stained slides were observed and detection of HPV DNA in cervical swabs was carried out with use of a polymerase chain reaction and microarrays technology. The relationship between the presence of HPV infection and diagnostic variables was evaluated. HPV 16 was the most common type followed by HPV 58, 51, 33 and 31. However, the two HPV types targeted in the prophylactic vaccines such as HPV type 16 and 18 were detected in only 37 (21.2%) and 2 (1.1%) cases respectively. Thirty-three (18.9%) of samples were infected with multiple types, the majority of them with two types. In addition, during the follow-up of patients many changes in type distribution were observed. Several studies will be necessary in order to evaluate the HPV type distribution for therapeutically and prophylactic purposes such as vaccine treatment. Also, because of the differences obtained depending of use of various DNA technologies, the performance of some comparative studies of the different methods from detection of HPV would be advisable in a high population of patients and with the most homogeneous conditions possible.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/871
Versión del editor : http://www.benthamscience.com/open/tovj/articles/V003/60TOVJ.htm
DOI: 10.2174/1874357900903010060
ISSN : 1874-3579 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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