Please use this identifier to cite or link to this item:
Title: Association of Streptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence.
Authors: Butt, Julia
Romero-Hernández, Beatriz
Pérez-Gómez, Beatriz
Willhauck-Fleckenstein, Martina
Holzinger, Dana
Martin, Vicente
Moreno, Victor
Linares, Cristina
Dierssen-Sotos, Trinidad
Barricarte, Aurelio
Tardón, Adonina
Altzibar, Jone M
Moreno-Osset, Eduardo
Franco, Francisco
Requena, Rocío Olmedo
Huerta, José María
Michel, Angelika
Waterboer, Tim
Castaño-Vinyals, Gemma
Kogevinas, Manolis
Pollán, Marina
Boleij, Annemarie
de Sanjosé, Silvia
Del Campo, Rosa
Tjalsma, Harold
Aragonés, Nuria
Pawlita, Michael
Keywords: antibodies;case-control study;epidemiology;gastrointestinal cancer;infection;pilus protein
metadata.dc.subject.mesh: Adult
Aged, 80 and over
Antibodies, Bacterial
Antigens, Bacterial
Case-Control Studies
Colorectal Neoplasms
Middle Aged
Seroepidemiologic Studies
Streptococcal Infections
Young Adult
Issue Date: 20-Nov-2015
Abstract: The colonic opportunist Streptococcus gallolyticus subspecies gallolyticus (SGG) is potentially associated with colorectal cancer (CRC). Large-scale seroepidemiological data for SGG antibodies and their possible association with CRC is currently missing. Associations between CRC and antibody responses to SGG were examined in 576 CRC cases and 576 controls matched by sex, age and province from a population-based multicase-control project (MCC-Spain). MCC-Spain was conducted between 2008 and 2013 in 12 Spanish provinces. Antibody responses to recombinant affinity-purified SGG pilus proteins Gallo1569, 2039, 2178 and 2179 were analysed by multiplex serology. Polyomavirus (PyV) JC VP1 and PyV 6 VP1 proteins served as disease-specificity controls. In the control population, antibody responses to pilus proteins were mostly weak. Antibody responses to individual pilus proteins Gallo2039 (OR: 1.58, 95% CI: 1.09-2.28), Gallo2178 (OR: 1.58, 95% CI: 1.09-2.30) and Gallo2179 (OR: 1.45, 95% CI: 1.00-2.11) were significantly associated with CRC risk. The association was stronger for positivity to two or more pilus proteins of Gallo1569, Gallo2178 and Gallo2179 (OR:1.93, 95% CI: 1.04-3.56) and for double-positivity to Gallo2178 and Gallo2179 (OR: 3.54, 95% CI: 1.49-8.44). The association between SGG infection and CRC risk was stronger among individuals younger than 65 years. For the first time we demonstrated a statistically significant association of exposure to SGG antigens and CRC in a large seroepidemiological study. These results should stimulate further studies on the role of SGG in CRC pathogenesis.
metadata.dc.identifier.doi: 10.1002/ijc.29914
Appears in Collections:Producción 2020

Files in This Item:
There are no files associated with this item.

This item is protected by original copyright

Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.