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Title: Vegetable and fruit consumption and the risk of hormone receptor-defined breast cancer in the EPIC cohort.
Authors: Emaus, Marleen J
Peeters, Petra H M
Bakker, Marije F
Overvad, Kim
Tjønneland, Anne
Olsen, Anja
Romieu, Isabelle
Ferrari, Pietro
Dossus, Laure
Boutron-Ruault, Marie Christine
Baglietto, Laura
Fortner, Renée T
Kaaks, Rudolf
Boeing, Heiner
Trichopoulou, Antonia
Lagiou, Pagona
Trichopoulos, Dimitrios
Masala, Giovanna
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Polidoro, Silvia
Skeie, Guri
Lund, Eiliv
Weiderpass, Elisabete
Quirós, J Ramón
Travier, Noémie
Sánchez, María-José
Chirlaque, Maria-Dolores
Ardanaz, Eva
Dorronsoro, Miren
Winkvist, Anna
Wennberg, Maria
Bueno-de-Mesquita, H Bas
Khaw, Kay-Tee
Travis, Ruth C
Key, Timothy J
Aune, Dagfinn
Gunter, Marc
Riboli, Elio
van Gils, Carla H
Keywords: breast cancer;estrogen receptor;fruit;progesterone receptor;vegetables
metadata.dc.subject.mesh: Adult
Breast Neoplasms
Feeding Behavior
Middle Aged
Proportional Hazards Models
Prospective Studies
Receptors, Estrogen
Receptors, Progesterone
Risk Factors
Issue Date: 25-Nov-2015
Abstract: The recent literature indicates that a high vegetable intake and not a high fruit intake could be associated with decreased steroid hormone receptor-negative breast cancer risk. This study aimed to investigate the association between vegetable and fruit intake and steroid hormone receptor-defined breast cancer risk. A total of 335,054 female participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were included in this study (mean ± SD age: 50.8 ± 9.8 y). Vegetable and fruit intake was measured by country-specific questionnaires filled out at recruitment between 1992 and 2000 with the use of standardized procedures. Cox proportional hazards models were stratified by age at recruitment and study center and were adjusted for breast cancer risk factors. After a median follow-up of 11.5 y (IQR: 10.1-12.3 y), 10,197 incident invasive breast cancers were diagnosed [3479 estrogen and progesterone receptor positive (ER+PR+); 1021 ER and PR negative (ER-PR-)]. Compared with the lowest quintile, the highest quintile of vegetable intake was associated with a lower risk of overall breast cancer (HRquintile 5-quintile 1: 0.87; 95% CI: 0.80, 0.94). Although the inverse association was most apparent for ER-PR- breast cancer (ER-PR-: HRquintile 5-quintile 1: 0.74; 95% CI: 0.57, 0.96; P-trend = 0.03; ER+PR+: HRquintile 5-quintile 1: 0.91; 95% CI: 0.79, 1.05; P-trend = 0.14), the test for heterogeneity by hormone receptor status was not significant (P-heterogeneity = 0.09). Fruit intake was not significantly associated with total and hormone receptor-defined breast cancer risk. This study supports evidence that a high vegetable intake is associated with lower (mainly hormone receptor-negative) breast cancer risk.
metadata.dc.identifier.doi: 10.3945/ajcn.114.101436
Appears in Collections:Producción 2020

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