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Title: Nutrient-wide association study of 57 foods/nutrients and epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study.
Authors: Merritt, Melissa A
Tzoulaki, Ioanna
van den Brandt, Piet A
Schouten, Leo J
Tsilidis, Konstantinos K
Weiderpass, Elisabete
Patel, Chirag J
Tjønneland, Anne
Hansen, Louise
Overvad, Kim
His, Mathilde
Dartois, Laureen
Boutron-Ruault, Marie-Christine
Fortner, Renée T
Kaaks, Rudolf
Aleksandrova, Krasimira
Boeing, Heiner
Trichopoulou, Antonia
Lagiou, Pagona
Bamia, Christina
Palli, Domenico
Krogh, Vittorio
Tumino, Rosario
Ricceri, Fulvio
Mattiello, Amalia
Bueno-de-Mesquita, H Bas
Onland-Moret, N Charlotte
Peeters, Petra H
Skeie, Guri
Jareid, Mie
Quirós, J Ramón
Obón-Santacana, Mireia
Sánchez, María-José
Chamosa, Saioa
Huerta, José M
Barricarte, Aurelio
Dias, Joana A
Sonestedt, Emily
Idahl, Annika
Lundin, Eva
Wareham, Nicholas J
Khaw, Kay-Tee
Travis, Ruth C
Ferrari, Pietro
Riboli, Elio
Gunter, Marc J
Keywords: diet;nutrition;ovarian cancer;prospective cohort;saturated fat;serous
metadata.dc.subject.mesh: Adult
Carcinoma, Ovarian Epithelial
Cohort Studies
Dietary Fats
Fatty Acids
Feeding Behavior
Middle Aged
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Risk Factors
Issue Date: 25-Nov-2015
Abstract: Studies of the role of dietary factors in epithelial ovarian cancer (EOC) development have been limited, and no specific dietary factors have been consistently associated with EOC risk. We used a nutrient-wide association study approach to systematically test the association between dietary factors and invasive EOC risk while accounting for multiple hypothesis testing by using the false discovery rate and evaluated the findings in an independent cohort. We assessed dietary intake amounts of 28 foods/food groups and 29 nutrients estimated by using dietary questionnaires in the EPIC (European Prospective Investigation into Cancer and Nutrition) study (n = 1095 cases). We selected 4 foods/nutrients that were statistically significantly associated with EOC risk when comparing the extreme quartiles of intake in the EPIC study (false discovery rate = 0.43) and evaluated these factors in the NLCS (Netherlands Cohort Study; n = 383 cases). Cox regression models were used to estimate HRs and 95% CIs. None of the 4 dietary factors that were associated with EOC risk in the EPIC study (cholesterol, polyunsaturated and saturated fat, and bananas) were statistically significantly associated with EOC risk in the NLCS; however, in meta-analysis of the EPIC study and the NLCS, we observed a higher risk of EOC with a high than with a low intake of saturated fat (quartile 4 compared with quartile 1; overall HR: 1.21; 95% CI: 1.04, 1.41). In the meta-analysis of both studies, there was a higher risk of EOC with a high than with a low intake of saturated fat.
metadata.dc.identifier.doi: 10.3945/ajcn.115.118588
Appears in Collections:Producción 2020

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