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Title: Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides.
Authors: Rodríguez, Carlos E
Palacios, Javier
Fajardo, Ignacio
Urdiales, José Luis
Le Guével, Xavier
Lozano, José
Sánchez-Jiménez, Francisca
Keywords: Graphene;MALDI-TOF/TOF;Phosphorylated peptides
metadata.dc.subject.mesh: Graphite
Signal Processing, Computer-Assisted
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Issue Date: 30-Nov-2015
Abstract: This is the first study where graphene is used as a MALDI adjuvant in combination with the traditional matrix α-cyano-4-hydroxycinnamic acid (CHCA) to improve the signal intensity of peptide samples. Use of this amended matrix not only leads to increased signals but also to a higher number of peaks detected in complex samples. Additionally, the use of graphene has a stabilizing effect that can also be exploited to improve the detection of easily cleavable molecules. Graphical Abstract ᅟ.
metadata.dc.identifier.doi: 10.1007/s13361-015-1299-3
Appears in Collections:Producción 2020

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