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Title: Analytical performance of the Alere™ i Influenza A&B assay for the rapid detection of influenza viruses.
Authors: Riazzo, Cristina
Pérez-Ruiz, Mercedes
Sanbonmatsu-Gámez, Sara
Pedrosa-Corral, Irene
Gutiérrez-Fernández, José
Navarro-Marí, José-María
Keywords: Detección rápida;Gripe;Influenza;Molecular testing;Método molecular;Rapid detection
metadata.dc.subject.mesh: Humans
Influenza A virus
Influenza B virus
Influenza, Human
Molecular Diagnostic Techniques
Nucleic Acid Amplification Techniques
Retrospective Studies
Time Factors
Issue Date: 25-Nov-2015
Abstract: The analytical performance of the new Alere™ i Influenza A&B kit (AL-Flu) assay, based on isothermal nucleic acids amplification, was evaluated and compared with an antigen detection method, SD Bioline Influenza Virus Antigen Test (SDB), and an automated real-time RT-PCR, Simplexa™ Flu A/B & VRS Direct assay (SPX), for detection of influenza viruses. An "in-house" RT-PCR was used as the reference method. Sensitivity of AL-Flu, SDB, and SPX was 71.7%, 34.8%, and 100%, respectively. Specificity was 100% for all techniques. The turnaround time was 13min for AL-Flu, 15min for SDB, and 75min for SPX. The Alere™ i Influenza A&B assay is an optimal point-of-care assay for influenza diagnosis in clinical emergency settings, and is more sensitive and specific than antigen detection methods.
metadata.dc.identifier.doi: 10.1016/j.eimc.2015.10.006
Appears in Collections:Producción 2020

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