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Title: Hyponatraemia, mortality and haemodialysis: An unexplained association.
Authors: Pérez-García, Rafael
Palomares, Inés
Merello, José Ignacio
Ramos, Rosa
Maduell, Francisco
Molina, Manolo
Aljama, Pedro
Marcelli, Daniele
ORD Group
Keywords: Diabetes;Haemodialysis;Hemodiálisis;Hiponatremia;Hyponatraemia;Mortalidad;Mortality;Natremia;Serum sodium
metadata.dc.subject.mesh: Aged
Cohort Studies
Diabetes Mellitus
Kidney Failure, Chronic
Renal Dialysis
Issue Date: 3-Dec-2015
Abstract: As in the general population, in patients on haemodialysis (HD) hyponatraemia is associated with higher mortality risk. The objective of this article was to study the relationship between predialysis serum sodium (sNa) and mortality in an HD population. We also intended to define hyponatraemia and determine the characteristics of hyponatraemic patients in terms of anthropometric data, analytical features, dialysis measurements and hydration (bioimpedance). Observational, descriptive study of a cohort of HD incident patients. The independent variable was the mean of each patient's sNa analysed during their first 6 months on HD. A total of 4,153 patients were included in the study. Mean age was 64.7 years; 65.2% of the patients were male and 35% were diabetics. Mean follow-up time was 21.48 (SD) (1.31) months. sNa had a normal distribution, with a mean (SD)=138.46 (2.7) mEq/l. Body weight, diabetes mellitus, systolic blood pressure, interdialytic weight gain, total ultrafiltration, serum glucose, albumin and creatinine, vascular access and haemodialysis type, acquire significant differences between sodium quartiles. Lean tissue index (LTI) in patients with low serum sodium, Q1 (135 mEq/l), was significantly lower than the LTI of patients from the other serum sodium quartiles. Patients with sNa HD patients with hyponatraemia patients have a poor prognosis and present malnutrition or fluid overload.
metadata.dc.identifier.doi: 10.1016/j.nefro.2015.10.005
Appears in Collections:Producción 2020

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