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Title: Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia.
Authors: Montull, Beatriz
Menéndez, Rosario
Torres, Antoni
Reyes, Soledad
Méndez, Raúl
Zalacaín, Rafael
Capelastegui, Alberto
Rajas, Olga
Borderías, Luis
Martin-Villasclaras, Juan
Bello, Salvador
Alfageme, Inmaculada
Rodríguez de Castro, Felipe
Rello, Jordi
Molinos, Luis
Ruiz-Manzano, Juan
NAC Calidad Group
metadata.dc.subject.mesh: Aged
Community-Acquired Infections
Length of Stay
Middle Aged
Pneumonia, Bacterial
Pneumonia, Viral
Prospective Studies
Risk Factors
Severity of Illness Index
Issue Date: 4-Jan-2016
Abstract: Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospitalized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age (>65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07-1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50-2.04) and renal disease (OR, 1.57; 95% CI, 1.21-2.03), whereas prior antibiotic treatment was a protective factor (OR, 0.62; 95% CI, 0.52-0.73). Bacteremia (OR, 1.37; 95% CI, 1.05-1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31-1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10-2.49) were associated with severe sepsis CAP. CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.
metadata.dc.identifier.doi: 10.1371/journal.pone.0145929
Appears in Collections:Producción 2020

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