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Title: Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort.
Authors: Bakker, Marije F
Peeters, Petra Hm
Klaasen, Veronique M
Bueno-de-Mesquita, H Bas
Jansen, Eugene Hjm
Ros, Martine M
Travier, Noémie
Olsen, Anja
Tjønneland, Anne
Overvad, Kim
Rinaldi, Sabina
Romieu, Isabelle
Brennan, Paul
Boutron-Ruault, Marie-Christine
Perquier, Florence
Cadeau, Claire
Boeing, Heiner
Aleksandrova, Krasimira
Kaaks, Rudolf
Kühn, Tilman
Trichopoulou, Antonia
Lagiou, Pagona
Trichopoulos, Dimitrios
Vineis, Paolo
Krogh, Vittorio
Panico, Salvatore
Masala, Giovanna
Tumino, Rosario
Weiderpass, Elisabete
Skeie, Guri
Lund, Eiliv
Quirós, J Ramón
Ardanaz, Eva
Navarro, Carmen
Amiano, Pilar
Sánchez, María-José
Buckland, Genevieve
Ericson, Ulrika
Sonestedt, Emily
Johansson, Matthias
Sund, Malin
Travis, Ruth C
Key, Timothy J
Khaw, Kay-Tee
Wareham, Nick
Riboli, Elio
van Gils, Carla H
Keywords: EPIC;antioxidants;breast cancer;carotenoids;plasma
metadata.dc.subject.mesh: Adult
Ascorbic Acid
Breast Neoplasms
Case-Control Studies
Cohort Studies
Follow-Up Studies
Middle Aged
Neoplasm Proteins
Prospective Studies
Receptors, Estrogen
Vitamin A
beta Carotene
Issue Date: 20-Jan-2016
Abstract: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity. This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer. In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for α-carotene, β-carotene, lycopene, lutein, zeaxanthin, β-cryptoxanthin, retinol, α-tocopherol, γ-tocopherol, and vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided. In quintile 5 compared with quintile 1, α-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and β-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER- breast tumors. The other analytes were not statistically associated with ER- breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER- and ER+ tumors was statistically significant only for β-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution). Our results indicate that higher concentrations of plasma β-carotene and α-carotene are associated with lower breast cancer risk of ER- tumors.
metadata.dc.identifier.doi: 10.3945/ajcn.114.101659
Appears in Collections:Producción 2020

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