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dc.contributor.authorAmo, Gemma
dc.contributor.authorGarcía-Menaya, Jesús
dc.contributor.authorCampo, Paloma
dc.contributor.authorCordobés, Concepción
dc.contributor.authorPlaza Serón, M Carmen
dc.contributor.authorAyuso, Pedro
dc.contributor.authorEsguevillas, Gara
dc.contributor.authorBlanca, Miguel
dc.contributor.authorAgúndez, Jose A G
dc.contributor.authorGarcía-Martín, Elena
dc.description.abstractAllergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the high-affinity IgE receptor (FcεRI), which is polymorphic. Studies analyzing the association between allergic rhinitis and FcεRI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in FcεRI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08-0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08-0.88, P = 0.020). These two SNPs are linked (D' = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.
dc.rightsAttribution 4.0 International
dc.subject.meshCase-Control Studies
dc.subject.meshGene Frequency
dc.subject.meshImmunoglobulin E
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshReceptors, IgE
dc.subject.meshRhinitis, Allergic
dc.titleA Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels.
dc.typeresearch article
dc.rights.accessRightsopen access
dc.journal.titleScientific reports
dc.journal.titleabbreviationSci Rep
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.organizationHospital Universitario Regional de Málaga
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
Appears in Collections:Producción 2020

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