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Title: An intensive lung donor treatment protocol does not have negative influence on other grafts: a multicentre study.
Authors: Miñambres, Eduardo
Pérez-Villares, Jose Miguel
Terceros-Almanza, Luis
Dueñas-Jurado, Jose María
Zabalegui, Arturo
Misis, Maite
Bouza, Maria Teresa
Ballesteros, María Angeles
Coll, Elisabeth
Keywords: Brain-dead donor;Lung donor;Multicentre study;Protocol
metadata.dc.subject.mesh: Adult
Brain Death
Clinical Protocols
Graft Survival
Lung Transplantation
Middle Aged
Organ Transplantation
Tissue Donors
Tissue and Organ Procurement
Issue Date: 19-Jan-2016
Abstract: Competing requirements for organ perfusion may call for antagonistic strategies such as fluid replacement or high positive end-expiratory pressure. We recently proposed an intensive lung donor treatment protocol that nearly tripled lung procurement rates and validated it in a multicentre study. The next step was to evaluate the impact of our proposal on the other organ grafts recovered from lung donors and on the recipients' outcome after transplantation of those grafts. A quasi-experimental study was conducted in six Spanish hospitals during 2013 (2010-12 was historical control). Organ donor management was led by a trained and experienced intensive care staff. A total of 618 actual donors after brain death (DBDs) were included, 453 DBDs in the control period (annual average 151) and 165 in the protocol period. No baseline differences were found between the periods. Heart, liver, kidney and pancreas retrieval rates were similar in both periods, and heart, liver, kidney and pancreas recipients' survival at 3 months showed no differences between both periods. Our lung donor treatment protocol is safe for other grafts obtained from donors undergoing these procedures with the aim of increasing lungs available for transplantation. It has no negative impact on the recovery rates of other grafts or on early survival of heart, liver, pancreas or kidney recipients.
metadata.dc.identifier.doi: 10.1093/ejcts/ezv454
Appears in Collections:Producción 2020

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