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Title: Non-vitamin K antagonist oral anticoagulants and antiphospholipid syndrome.
Authors: Sciascia, Savino
Lopez-Pedrera, Chary
Cecchi, Irene
Pecoraro, Clara
Roccatello, Dario
Cuadrado, Maria Josè
Keywords: anti-phospholipid antibodies;anti-phospholipid syndrome;apixaban;dabigatran;rivaroxaban;thrombosis
metadata.dc.subject.mesh: Administration, Oral
Antiphospholipid Syndrome
Breast Feeding
Factor Xa Inhibitors
Food-Drug Interactions
Kidney Diseases
Liver Diseases
Lupus Coagulation Inhibitor
Pregnancy Complications
Vitamin K
Issue Date: 3-Feb-2016
Abstract: The current treatment of thrombotic APS patients includes long-term anticoagulation with oral vitamin K antagonists (VKAs), with warfarin being the one most commonly used. However, the use of VKAs can be challenging, especially in patients with APS. VKAs monitoring in patients with aPL is complicated by the heterogeneous responsiveness to LAs of reagents used in the International Normalized Ratio test, potentially resulting in instability of anticoagulation. For decades, VKAs were the only available oral anticoagulants. However, non-VKA oral anticoagulants, including a direct thrombin inhibitor (dabigatran etexilate) and direct anti-Xa inhibitors (rivaroxaban, apixaban and edoxaban), are currently available. The use of these agents may represent a major step forward since, unlike VKAs, they have few reported drug interactions and they do not interact with food or alcohol intake, thereby resulting in more stable anticoagulant intensity. Most importantly, monitoring their anticoagulant intensity is not routinely required due to their predictable anticoagulant effects. In this review, we discuss the clinical and laboratory aspects of non-VKA oral anticoagulants, focusing on the available evidence regarding their use in patients with APS.
metadata.dc.identifier.doi: 10.1093/rheumatology/kev445
Appears in Collections:Producción 2020

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