Please use this identifier to cite or link to this item:
|Title:||Non-vitamin K antagonist oral anticoagulants and antiphospholipid syndrome.|
Cuadrado, Maria Josè
|Keywords:||anti-phospholipid antibodies;anti-phospholipid syndrome;apixaban;dabigatran;rivaroxaban;thrombosis|
Factor Xa Inhibitors
Lupus Coagulation Inhibitor
|Abstract:||The current treatment of thrombotic APS patients includes long-term anticoagulation with oral vitamin K antagonists (VKAs), with warfarin being the one most commonly used. However, the use of VKAs can be challenging, especially in patients with APS. VKAs monitoring in patients with aPL is complicated by the heterogeneous responsiveness to LAs of reagents used in the International Normalized Ratio test, potentially resulting in instability of anticoagulation. For decades, VKAs were the only available oral anticoagulants. However, non-VKA oral anticoagulants, including a direct thrombin inhibitor (dabigatran etexilate) and direct anti-Xa inhibitors (rivaroxaban, apixaban and edoxaban), are currently available. The use of these agents may represent a major step forward since, unlike VKAs, they have few reported drug interactions and they do not interact with food or alcohol intake, thereby resulting in more stable anticoagulant intensity. Most importantly, monitoring their anticoagulant intensity is not routinely required due to their predictable anticoagulant effects. In this review, we discuss the clinical and laboratory aspects of non-VKA oral anticoagulants, focusing on the available evidence regarding their use in patients with APS.|
|Appears in Collections:||Producción 2020|
Files in This Item:
There are no files associated with this item.
This item is protected by original copyright
Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.