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Title: Development and validation of a noninvasive prediction model for nonalcoholic steatohepatitis resolution after lifestyle intervention.
Authors: Vilar-Gomez, Eduardo
Yasells-Garcia, Ali
Martinez-Perez, Yadina
Calzadilla-Bertot, Luis
Torres-Gonzalez, Ana
Gra-Oramas, Bienvenido
Gonzalez-Fabian, Licet
Villa-Jimenez, Oscar
Friedman, Scott L
Diago, Moises
Romero-Gomez, Manuel
metadata.dc.subject.mesh: Adult
Life Style
Middle Aged
Models, Theoretical
Multivariate Analysis
Non-alcoholic Fatty Liver Disease
Issue Date: 10-Mar-2016
Abstract: Liver biopsy is the gold standard method to assess nonalcoholic steatohepatitis (NASH) resolution after therapeutic interventions. We developed and validated a simple and noninvasive scoring system to predict NASH resolution without fibrosis worsening after 1 year of lifestyle intervention. This was a prospective cohort study conducted in 261 patients with histologically proven NASH who were treated with lifestyle changes for 52 weeks and underwent a second liver biopsy to confirm NASH resolution. We divided the data into development (140 subjects) and validation (121 individuals) sets. NASH resolution occurred in 28% (derivation group) and 27% (validation group). At the multivariable analysis, weight loss (odds ratio [OR] = 2.75, 95% confidence interval [CI] 1.65-4.58; P A noninvasive prediction model including weight loss, type 2 diabetes, alanine aminotransferase normalization, age, and a nonalcoholic fatty liver activity score ≥5 may be useful to identify NASH resolution in patients under lifestyle intervention. (Hepatology 2016;63:1875-1887).
metadata.dc.identifier.doi: 10.1002/hep.28484
Appears in Collections:Producción 2020

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