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Title: Role of the satiety factor oleoylethanolamide in alcoholism.
Authors: Bilbao, Ainhoa
Serrano, Antonia
Cippitelli, Andrea
Pavón, Francisco J
Giuffrida, Andrea
Suárez, Juan
García-Marchena, Nuria
Baixeras, Elena
Gómez de Heras, Raquel
Orio, Laura
Alén, Francisco
Ciccocioppo, Roberto
Cravatt, Benjamin F
Parsons, Loren H
Piomelli, Daniele
Rodríguez de Fonseca, Fernando
Keywords: Alcohol self-administration;PPAR-α;alcoholism;oleoylethanolamide;relapse
metadata.dc.subject.mesh: Alcohol Drinking
Disease Models, Animal
Oleic Acids
PPAR alpha
Rats, Wistar
Satiety Response
Signal Transduction
Issue Date: 2-Jun-2015
Abstract: Oleoylethanolamide (OEA) is a satiety factor that controls motivational responses to dietary fat. Here we show that alcohol administration causes the release of OEA in rodents, which in turn reduces alcohol consumption by engaging peroxisome proliferator-activated receptor-alpha (PPAR-α). This effect appears to rely on peripheral signaling mechanisms as alcohol self-administration is unaltered by intracerebral PPAR-α agonist administration, and the lesion of sensory afferent fibers (by capsaicin) abrogates the effect of systemically administered OEA on alcohol intake. Additionally, OEA is shown to block cue-induced reinstatement of alcohol-seeking behavior (an animal model of relapse) and reduce the severity of somatic withdrawal symptoms in alcohol-dependent animals. Collectively, these findings demonstrate a homeostatic role for OEA signaling in the behavioral effects of alcohol exposure and highlight OEA as a novel therapeutic target for alcohol use disorders and alcoholism.
metadata.dc.identifier.doi: 10.1111/adb.12276
Appears in Collections:Producción 2020

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