Please use this identifier to cite or link to this item:
Title: Circulating Tumor Cells Identify Early Recurrence in Patients with Non-Small Cell Lung Cancer Undergoing Radical Resection.
Authors: Bayarri-Lara, Clara
Ortega, Francisco G
Cueto Ladrón de Guevara, Antonio
Puche, Jose L
Ruiz Zafra, Javier
de Miguel-Pérez, Diego
Ramos, Abel Sánchez-Palencia
Giraldo-Ospina, Carlos Fernando
Navajas Gómez, Juan A
Delgado-Rodriguez, Miguel
Lorente, Jose A
Serrano, María Jose
metadata.dc.subject.mesh: Adult
Aged, 80 and over
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
Cohort Studies
ErbB Receptors
Longitudinal Studies
Lung Neoplasms
Middle Aged
Neoplasm Recurrence, Local
Neoplastic Cells, Circulating
Prospective Studies
Issue Date: 25-Feb-2016
Abstract: Surgery is the treatment of choice for patients with non-small cell lung cancer (NSCLC) stages I-IIIA. However, more than 20% of these patients develop recurrence and die due to their disease. The release of tumor cells into peripheral blood (CTCs) is one of the main causes of recurrence of cancer. The objectives of this study are to identify the prognostic value of the presence and characterization of CTCs in peripheral blood in patients undergoing radical resection for NSCLC. 56 patients who underwent radical surgery for previously untreated NSCLC were enrolled in this prospective study. Peripheral blood samples for CTC analysis were obtained before and one month after surgery. In addition CTCs were phenotypically characterized by epidermal growth factor receptor (EGFR) expression. 51.8% of the patients evaluated were positive with the presence of CTCs at baseline. A decrease in the detection rate of CTCs was observed in these patients one month after surgery (32.1%) (p = 0.035). The mean number of CTCs was 3.16 per 10 ml (range 0-84) preoperatively and 0.66 (range 0-3) in postoperative determination. EGFR expression was found in 89.7% of the patients at baseline and in 38.9% patients one month after surgery. The presence of CTCs after surgery was significantly associated with early recurrence (p = 0.018) and a shorter disease free survival (DFS) (p = .008). In multivariate analysis CTC presence after surgery (HR = 5.750, 95% CI: 1.50-21.946, p = 0.010) and N status (HR = 0.296, 95% CI: 0.091-0.961, p = 0.043) were independent prognostic factors for DFS. CTCs can be detected and characterized in patients undergoing radical resection for non-small cell lung cancer. Their presence might be used to identify patients with increased risk of early recurrence.
metadata.dc.identifier.doi: 10.1371/journal.pone.0148659
Appears in Collections:Producción 2020

Files in This Item:
File SizeFormat 
PMC4767413.pdf1,38 MBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons