Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models.

Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/9867

Title:	Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models.
Authors:	Gallardo, Elena Sarria, Beatriz Espartero, José Luis Gonzalez Correa, José Antonio Bravo-Clemente, Laura Mateos, Raquel
Keywords:	Parkinson’s disease;bioavailability;hydroxytyrosol;metabolism;nitrocatechols
metadata.dc.subject.mesh:	Biological Availability Caco-2 Cells Hep G2 Cells Humans Hydrolysis Intestinal Mucosa Liver Models, Biological Nitro Compounds Phenylethyl Alcohol
Issue Date:	10-Mar-2016
Abstract:	Considering that nitrocatechols present putative effects against Parkinson's disease, the absorption and metabolism of nitroderivatives of hydroxytyrosol (HT) were assessed using human cell model systems. The test compounds nitrohydroxytyrosol (NO2HT), nitrohydroxytyrosyl acetate (NO2HT-A), and ethyl nitrohydroxytyrosyl ether (NO2HT-E) were efficiently transferred across human Caco-2 cell monolayers as an intestinal barrier model, NO2HT-A and NO2HT-E being better (p
URI:	http://hdl.handle.net/10668/9867
metadata.dc.identifier.doi:	10.1021/acs.jafc.6b00401
Appears in Collections:	Producción 2020

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