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Title: Evaluation of the Bioavailability and Metabolism of Nitroderivatives of Hydroxytyrosol Using Caco-2 and HepG2 Human Cell Models.
Authors: Gallardo, Elena
Sarria, Beatriz
Espartero, José Luis
Gonzalez Correa, José Antonio
Bravo-Clemente, Laura
Mateos, Raquel
Keywords: Parkinson’s disease;bioavailability;hydroxytyrosol;metabolism;nitrocatechols
metadata.dc.subject.mesh: Biological Availability
Caco-2 Cells
Hep G2 Cells
Intestinal Mucosa
Models, Biological
Nitro Compounds
Phenylethyl Alcohol
Issue Date: 10-Mar-2016
Abstract: Considering that nitrocatechols present putative effects against Parkinson's disease, the absorption and metabolism of nitroderivatives of hydroxytyrosol (HT) were assessed using human cell model systems. The test compounds nitrohydroxytyrosol (NO2HT), nitrohydroxytyrosyl acetate (NO2HT-A), and ethyl nitrohydroxytyrosyl ether (NO2HT-E) were efficiently transferred across human Caco-2 cell monolayers as an intestinal barrier model, NO2HT-A and NO2HT-E being better (p
metadata.dc.identifier.doi: 10.1021/acs.jafc.6b00401
Appears in Collections:Producción 2020

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