Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.

Chuang, Shu-Chun; Boeing, Heiner; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Bueno-de-Mesquita, Bas; Lajous, Martin; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Kaaks, Rudolf; Küehn, Tilman; Pischon, Tobias; Drogan, Dagmar; Tjønneland, Anne; Overvad, Kim; Quirós, J Ramón; Agudo, Antonio; Molina-Montes, Esther; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nicholas J; Travis, Ruth C; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Mattiello, Amalia; Peeters, Petra H; Weiderpass, Elisabete; Palmqvist, Richard; Ljuslinder, Ingrid; Gunter, Marc; Lu, Yunxia; Cross, Amanda J; Riboli, Elio; Vineis, Paolo; Aleksandrova, Krasimira

Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/9869

Title:	Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.
Authors:	Chuang, Shu-Chun Boeing, Heiner Vollset, Stein Emil Midttun, Øivind Ueland, Per Magne Bueno-de-Mesquita, Bas Lajous, Martin Fagherazzi, Guy Boutron-Ruault, Marie-Christine Kaaks, Rudolf Küehn, Tilman Pischon, Tobias Drogan, Dagmar Tjønneland, Anne Overvad, Kim Quirós, J Ramón Agudo, Antonio Molina-Montes, Esther Dorronsoro, Miren Huerta, José María Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nicholas J Travis, Ruth C Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios Masala, Giovanna Agnoli, Claudia Tumino, Rosario Mattiello, Amalia Peeters, Petra H Weiderpass, Elisabete Palmqvist, Richard Ljuslinder, Ingrid Gunter, Marc Lu, Yunxia Cross, Amanda J Riboli, Elio Vineis, Paolo Aleksandrova, Krasimira
Keywords:	Cell-mediated immunity;Metabolic syndrome;Neopterin
Issue Date:	25-Feb-2016
Abstract:	Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.
URI:	http://hdl.handle.net/10668/9869
metadata.dc.identifier.doi:	10.1186/s12979-016-0059-y
ISSN:	1742-4933
Appears in Collections:	Producción 2020

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