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Title: Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.
Authors: Chuang, Shu-Chun
Boeing, Heiner
Vollset, Stein Emil
Midttun, Øivind
Ueland, Per Magne
Bueno-de-Mesquita, Bas
Lajous, Martin
Fagherazzi, Guy
Boutron-Ruault, Marie-Christine
Kaaks, Rudolf
Küehn, Tilman
Pischon, Tobias
Drogan, Dagmar
Tjønneland, Anne
Overvad, Kim
Quirós, J Ramón
Agudo, Antonio
Molina-Montes, Esther
Dorronsoro, Miren
Huerta, José María
Barricarte, Aurelio
Khaw, Kay-Tee
Wareham, Nicholas J
Travis, Ruth C
Trichopoulou, Antonia
Lagiou, Pagona
Trichopoulos, Dimitrios
Masala, Giovanna
Agnoli, Claudia
Tumino, Rosario
Mattiello, Amalia
Peeters, Petra H
Weiderpass, Elisabete
Palmqvist, Richard
Ljuslinder, Ingrid
Gunter, Marc
Lu, Yunxia
Cross, Amanda J
Riboli, Elio
Vineis, Paolo
Aleksandrova, Krasimira
Keywords: Cell-mediated immunity;Metabolic syndrome;Neopterin
Issue Date: 25-Feb-2016
Abstract: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p  These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.
metadata.dc.identifier.doi: 10.1186/s12979-016-0059-y
ISSN: 1742-4933
Appears in Collections:Producción 2020

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