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Title: Combined LC/UV/MS and NMR Strategies for the Dereplication of Marine Natural Products.
Authors: Pérez-Victoria, Ignacio
Martín, Jesús
Reyes, Fernando
metadata.dc.subject.mesh: Animals
Aquatic Organisms
Biological Products
Chromatography, Liquid
Drug Discovery
Magnetic Resonance Imaging
Mass Spectrometry
Issue Date: 22-Mar-2016
Abstract: Drug discovery from marine natural products has experienced a revival since the beginning of this century. To be successful in this field, rapid dereplication (identification of already known bioactive compounds) is essential in order to assess the chemical novelty of crude extracts and their fractions. Access to the appropriate state-of-the-art analytical instrumentation and to suitable databases is a fundamental requirement in such a task. A brief survey of the most robust LC/UV/MS- and NMR-based approaches employed for marine natural product dereplication is presented alongside a description of the procedures followed to achieve this goal in our research group.
metadata.dc.identifier.doi: 10.1055/s-0042-101763
Appears in Collections:Producción 2020

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