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Title: Aging-associated oxidized albumin promotes cellular senescence and endothelial damage.
Authors: Luna, Carlos
Alique, Matilde
Navalmoral, Estefanía
Noci, Maria-Victoria
Bohorquez-Magro, Lourdes
Carracedo, Julia
Ramírez, Rafael
Keywords: elderly;microparticles;oxidative stress;vascular damage
metadata.dc.subject.mesh: Adult
Advanced Oxidation Protein Products
Aged, 80 and over
Case-Control Studies
Cells, Cultured
Cellular Senescence
Endothelial Cells
Oxidative Stress
Risk Factors
Serum Albumin
Issue Date: 29-Feb-2016
Abstract: Increased levels of oxidized proteins with aging have been considered a cardiovascular risk factor. However, it is unclear whether oxidized albumin, which is the most abundant serum protein, induces endothelial damage. The results of this study indicated that with aging processes, the levels of oxidized proteins as well as endothelial microparticles release increased, a novel marker of endothelial damage. Among these, oxidized albumin seems to play a principal role. Through in vitro studies, endothelial cells cultured with oxidized albumin exhibited an increment of endothelial damage markers such as adhesion molecules and apoptosis levels. In addition, albumin oxidation increased the amount of endothelial microparticles that were released. Moreover, endothelial cells with increased oxidative stress undergo senescence. In addition, endothelial cells cultured with oxidized albumin shown a reduction in endothelial cell migration measured by wound healing. As a result, we provide the first evidence that oxidized albumin induces endothelial injury which then contributes to the increase of cardiovascular disease in the elderly subjects.
metadata.dc.identifier.doi: 10.2147/CIA.S91453
Appears in Collections:Producción 2020

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