Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer.
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Identifiers
Date
2020-04-24
Authors
Peñate, Xenia
Praena-Fernandez, Juan Manuel
Romero-Pareja, Pedro
Enguix-Riego, María Del Valle
Payan-Bravo, Laura
Vieites, Begoña
Gomez-Izquierdo, Lourdes
Jaen-Olasolo, Javier
Rivin-Del-Campo, Eleonor
Reyes, Jose Carlos
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI AG
Abstract
Canonical prefoldin is a protein cochaperone composed of six different subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial-mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) cell lines. We investigated whether this putative involvement of canonical PFDN in LC translates into the clinic. First, the mRNA expression of 518 non-small cell LC (NSCLC) cases from The Cancer Genome Atlas (TCGA) database was evaluated. Patients with PFDN1 overexpression had lower overall survival (OS; 45 vs. 86 months; p = 0.034). We then assessed the impact of PFDN expression on outcome in 58 NSCLC patients with available tumor tissue samples. PFDN1, 3, and 5 overexpression were found in 38% (n = 22), 53% (n = 31), and 41% (n = 24) of tumor samples. PFDN1, 3, and 5 overexpression were significantly associated with lower OS, lower disease-free survival (DFS), and lower distant metastasis-free survival (DMFS) for PFDN1 and 3 with a trend for PFDN5. In multivariate analysis, PFDN5 retained significance for OS (hazard ratio (HR) 2.56; p = 0.007) and PFDN1 for DFS (HR 2.53; p = 0.010) and marginally for DMFS (HR 2.32; p = 0.053). Our results indicate that protein response markers, such as PFDN1, 3, and 5, may complement mRNA signatures and be useful for determining the most appropriate therapy for NSCLC patients.
Description
MeSH Terms
Lung Neoplasms
prefoldin
Disease-Free Survival
Heterografts
Cell Line
Epithelial-Mesenchymal Transition
prefoldin
Disease-Free Survival
Heterografts
Cell Line
Epithelial-Mesenchymal Transition
DeCS Terms
Neoplasias
Proteínas
Xenoinjertos
Crecimiento
Metástasis de la neoplasia
Proteínas
Xenoinjertos
Crecimiento
Metástasis de la neoplasia
CIE Terms
Keywords
metastasis, non-small cell lung cancer, prefoldin, survival
Citation
Peñate X, Praena-Fernández JM, Romero Pareja P, Enguix-Riego MDV, Payán-Bravo L, Vieites B, et al. Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer. Cancers (Basel). 2020 Apr 24;12(4):1052.